Department of Diagnostic and Therapeutic Radiology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan,
Jpn J Radiol. 2013 Sep;31(9):633-6. doi: 10.1007/s11604-013-0221-9. Epub 2013 Jun 2.
We present a case of multifocal micronodular pneumocyte hyperplasia (MMPH), lymphangiomyomatosis (LAM) and angiomyolipoma (AML) in a 33-year-old woman with tuberous sclerosis complex referred to us during her first pregnancy. Computed tomography of the chest showed diffuse micronodules and cysts in both lungs. Compared to those before pregnancy, the number of micronodules increased evidently. We hypothesized the micronodules in both lungs were either LAM, MMPH, or a combination of the two. Bilateral renal AML also intensified. About one month after childbirth, LAM and renal AML decreased without treatment. Therefore, we observed that LAM and AML were affected by the pregnancy. To the best of our knowledge, this is the first case report regarding the reversible alteration of LAM without treatment.
我们报告了一例结节性肺泡细胞增生症（MMPH）、淋巴管平滑肌瘤病（LAM）和血管平滑肌脂肪瘤（AML），患者为 33 岁女性，患有结节性硬化症，在其首次妊娠期间就诊。胸部计算机断层扫描显示双肺弥漫性微结节和囊肿。与妊娠前相比，微结节的数量明显增加。我们推测双肺的微结节要么是 LAM，要么是 MMPH，要么是两者的组合。双侧肾 AML 也加重了。大约在产后一个月，LAM 和肾 AML 未经治疗就减少了。因此，我们观察到 LAM 和 AML 受到妊娠的影响。据我们所知，这是首例未经治疗的 LAM 可逆改变的病例报告。
