Department of Radiation Oncology, Peter MacCallum Cancer Centre, Victoria, Australia; The University of Melbourne, Grattan Street, Parkville, Victoria, Australia.
Head Neck. 2014 Mar;36(3):317-22. doi: 10.1002/hed.23297. Epub 2013 Jun 1.
The primary purpose of this study was to review the efficacy of unilateral treatment of lateralized tonsil primaries, in particular whether laterality of the primary is a more powerful determinant of contralateral neck failure than advanced ipsilateral nodal classification.
A retrospective study of all patients with tonsillar cancer treated with curative intent between January 1990 and December 2002 was performed.
There were 167 patients, 76% men, median age 58 years, 86% current or ex-smokers. The majority of patients (58%) had stage IV disease. Five-year local, nodal, locoregional, and distant failure rates were 14%, 4%, 18%, and 8%, respectively. Of the 58 patients treated unilaterally, 33% had N2a, N2b, or N3 nodal disease. There were no contralateral nodal failures in the unilaterally treated group.
These results support the potential use of unilateral radiation therapy (RT) for lateralized tonsil primaries even with advanced ipsilateral nodal disease.
本研究的主要目的是回顾单侧治疗单侧扁桃体原发性肿瘤的疗效，特别是原发性肿瘤的侧别是否比同侧淋巴结高级别分类更能决定对侧颈部失败。
对 1990 年 1 月至 2002 年 12 月期间接受根治性治疗的所有扁桃体癌患者进行了回顾性研究。
共有 167 例患者，男性占 76%，中位年龄 58 岁，86%为现吸烟者或既往吸烟者。大多数患者（58%）为 IV 期疾病。5 年局部、区域淋巴结、局部区域和远处失败率分别为 14%、4%、18%和 8%。在单侧治疗的 58 例患者中，有 33%的患者存在 N2a、N2b 或 N3 淋巴结疾病。单侧治疗组无对侧淋巴结转移失败。
这些结果支持对单侧扁桃体原发性肿瘤，即使同侧淋巴结高级别分类，也可采用单侧放疗。
