Zhai Lingling, Zhao Jian, Bai Yinglong, Liu Li, Zheng Linlin, Jia Lihong, Yao Xingjia
J Pediatr Endocrinol Metab. 2013;26(9-10):895-901. doi: 10.1515/jpem-2012-0398.
The objective of the study was to evaluate whether or not sexual development differs between boys with prepubertal obesity and boys of normal weight. We enrolled healthy obese and normoweight schoolboys from Shenyang City, Liaoning, China. Eligible boys were at Tanner stage 1 and 8 years of age at baseline. We measured testosterone and estradiol concentrations in the saliva and assessed auxology annually for 4 years. In all 56 obese and 56 normoweight boys, the height, weight, body composition, and sex organ volume increased with age. The percentages of body fat, fat mass, and lean mass were all higher in obese than in normoweight boys. The mean testicular volume was smaller in obese boys than in normoweight boys. The sex hormone concentrations increased with age, except for testosterone in obese boys in year 3 of follow-up. In year 4, estradiol concentrations were significantly higher in obese boys than in normoweight boys. Excessive adiposity in prepubertal boys might affect testicular volume, possibly because of high estradiol and low testosterone concentrations.
该研究的目的是评估青春期前肥胖男孩与正常体重男孩的性发育是否存在差异。我们从中国辽宁省沈阳市招募了健康的肥胖和正常体重男学生。符合条件的男孩在基线时处于坦纳1期且年龄为8岁。我们测量了唾液中的睾酮和雌二醇浓度，并在4年中每年评估人体测量学指标。在所有56名肥胖男孩和56名正常体重男孩中，身高、体重、身体成分和性器官体积均随年龄增加。肥胖男孩的体脂百分比、脂肪量和瘦体重均高于正常体重男孩。肥胖男孩的平均睾丸体积小于正常体重男孩。除了随访第3年肥胖男孩的睾酮外，性激素浓度随年龄增加。在第4年，肥胖男孩的雌二醇浓度显著高于正常体重男孩。青春期前男孩的过度肥胖可能会影响睾丸体积，这可能是由于高雌二醇和低睾酮浓度所致。
