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择期行肺叶切除术的患者仅进行血型与配型检测的策略安全吗?

Is type and screen only policy safe for patients undergoing elective lobectomy?

机构信息

Department of Cardiothoracic Surgery, University Hospital of South Manchester, Manchester, UK.

出版信息

Eur J Cardiothorac Surg. 2013 Dec;44(6):1113-6; discussion 116. doi: 10.1093/ejcts/ezt209. Epub 2013 May 31.

Abstract

OBJECTIVE

The purpose of this study was to establish the safety and feasibility of a recently adopted policy to type and screen (TS) (group and save) only for selected patients who had low likelihood of transfusion requirement.

METHODS

The TS only policy was applied to patients undergoing first-time elective lobectomy with Hb of >11 g/dl, aged <70 years, with no clotting abnormality and no history of neoadjuvant therapy. A retrospective analysis of prospectively collected data was made of 208 consecutive patients undergoing elective lobectomy from November 2009 to October 2010. The patients who were only type and screened (Group TS, n = 87) were compared with those who had preoperative cross matching (XM) (Group XM, n = 121). The perioperative characteristics, transfusion requirements and outcomes were compared between the two groups.

RESULTS

Preoperative characteristics of the two groups were similar, except that the XM group were significantly older, with lower mean preoperative haemoglobin levels. Postoperative complications (9 vs 13%, P = 0.24) and hospital mortality (0 vs 0.8%, P = 0.5) were similar between TS and XM, respectively. On the day of operation, 16 patients (13%) required transfusion in the XM group. Six patients in the TS group were cross matched, of whom only 3 (3.4%) actually required transfusion. The mean postoperative Hb levels in XM were also significantly lower (12.96 vs 10.88 gm/dl). In the XM group, 260 units of blood were unnecessarily cross matched and had to be returned to the blood bank compared with zero units in the TS group. There was no delay caused by unavailability of blood at the time of clinical need.

CONCLUSION

Our data suggest that it is safe and feasible to adopt a policy of type and screen only in selected patients undergoing elective lobectomy, who have low likelihood of transfusion requirement.

摘要

目的

本研究旨在评估仅对低输血需求可能性的特定患者进行定型和筛查(TS)(分组和保存)的最新采用政策的安全性和可行性。

方法

仅采用 TS 政策对 Hb > 11 g/dl、年龄<70 岁、无凝血异常且无新辅助治疗史的首次择期行 lobectomy 的患者进行。对 2009 年 11 月至 2010 年 10 月期间连续 208 例行择期 lobectomy 的患者前瞻性收集的数据进行回顾性分析。将仅定型和筛查(TS 组,n = 87)的患者与进行术前交叉配血(XM 组,n = 121)的患者进行比较。比较两组的围手术期特征、输血需求和结果。

结果

两组患者的术前特征相似,但 XM 组患者年龄较大,平均术前血红蛋白水平较低。两组患者的术后并发症(9%比 13%,P = 0.24)和院内死亡率(0%比 0.8%,P = 0.5)均相似。在手术当天,XM 组有 16 例(13%)患者需要输血。TS 组有 6 例患者进行了交叉配血,其中只有 3 例(3.4%)实际需要输血。XM 组患者术后平均 Hb 水平也显著较低(12.96 比 10.88 gm/dl)。在 XM 组,有 260 单位血液不需要交叉配血,但必须返还血库,而 TS 组无此情况。在临床需要时,没有因血液不可用而导致的延迟。

结论

我们的数据表明,在低输血需求可能性的特定择期 lobectomy 患者中,采用仅定型和筛查的政策是安全且可行的。

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