H A Krishnamurthy
Associate Professor, Department of General Medicine, Srinivasa Institute of Medical Sciences and Research Center , Mukka, Surathkal, Mangalore, Karnataka-574146, India .
J Clin Diagn Res. 2013 Apr;7(4):691-4. doi: 10.7860/JCDR/2013/5569.2883. Epub 2013 Mar 9.
The serum gamma glutamyl transpeptidase (GGT) levels rise and return to normal levels later in the chronic anicteric non alcoholic liver diseases than the transaminases levels. So, the estimation of GGT is of some value in monitoring the progress of acute to chronic hepatitis, when the values persist in high levels.
To evaluate the serum GGT levels in patients with chronic anicteric non alcoholic liver diseases and to show that it can be used as a noninvasive diagnostic biomarker for the diagnosis of chronic anicteric non alcoholic liver disorders.
This was a case control study, in which 50 cases and 50 controls were selected.The liver function tests with a special reference to the serum level of GGT were measured in the laboratory for both the cases and the controls and the serum GGT levels of the cases were compared with those of the controls. The Chi-square and the Fisher exact tests were used to find the significance of the proportions of the study parameters between the cases and the controls. The Student's t test (two tailed) was used to find the significance mean pattern of the study parameters between the cases and the controls.
The mean serum GGT level was 38.73±11 IU/L in the cases and in the controls, it was 20.42±9 IU/L(p<0.001).The mean value of serum ALT was 41.37±12.5 vs 16.3±8iu/l(p<0.001), that of AST was 28.14±8 vs 17.56±8.5iu/l(p<0.05), that of total bilirubin was 0.9±0.3 vs 0.5±0.2mg/dl and that of serum albumin was 4.17±0.6 vs 4.5±0.75gm/dl, as were seen in the cases and the controls respectively.
The serum gamma glutamyl transpeptidase level was elevated more consistently along with the alanine transaminase level in all types of anicteric nonalcoholic chronic liver diseases. The alanine transminase level has already been proved to be a marker in the diagnosis of chronic anicteric nonalcoholic liver diseases. So, in view of the persistent elevation, along with the high sensitivity, the elevated gamma glutamyl transpeptidase level can also be used as a noninvasive bio marker of chronic anicteric nonalcoholic liver diseases for both diagnostic and therapeutic purposes.
在慢性无黄疸型非酒精性肝病中，血清γ-谷氨酰转肽酶（GGT）水平升高，且比转氨酶水平恢复正常的时间更晚。因此，当GGT值持续处于高水平时，其测定对于监测急性肝炎向慢性肝炎的进展具有一定价值。
评估慢性无黄疸型非酒精性肝病患者的血清GGT水平，并证明其可作为诊断慢性无黄疸型非酒精性肝病的非侵入性诊断生物标志物。
这是一项病例对照研究，选取了50例病例和50例对照。在实验室对病例组和对照组均进行了肝功能检查，特别关注血清GGT水平，并将病例组的血清GGT水平与对照组进行比较。采用卡方检验和Fisher精确检验来确定病例组和对照组之间研究参数比例的显著性。使用Student's t检验（双侧）来确定病例组和对照组之间研究参数均值模式的显著性。
病例组血清GGT的平均水平为38.73±11 IU/L，对照组为20.42±9 IU/L（p<0.001）。病例组血清ALT的平均值为41.37±12.5，对照组为16.3±8 IU/L（p<0.001）；AST的平均值分别为28.14±8和17.56±8.5 IU/L（p<0.05）；总胆红素的平均值分别为0.9±0.3和0.5±0.2mg/dl；血清白蛋白的平均值分别为4.17±0.6和4.5±0.75g/dl。
在所有类型的无黄疸型非酒精性慢性肝病中，血清γ-谷氨酰转肽酶水平与丙氨酸转氨酶水平一样，更持续地升高。丙氨酸转氨酶水平已被证明是诊断慢性无黄疸型非酒精性肝病的一个标志物。因此，鉴于γ-谷氨酰转肽酶水平持续升高以及高敏感性，其升高水平也可作为慢性无黄疸型非酒精性肝病的非侵入性生物标志物，用于诊断和治疗目的。
