泪腺对 (67)Ga-枸橼酸镓的摄取与疑似肉样瘤病患者的活检结果相关。

Lacrimal gland uptake of (67)Ga-gallium citrate correlates with biopsy results in patients with suspected sarcoidosis.

机构信息

Department of Ophthalmology, Mount Sinai School of Medicine , New York, New York , USA .

出版信息

Ocul Immunol Inflamm. 2014 Feb;22(1):15-22. doi: 10.3109/09273948.2013.791700. Epub 2013 Jun 3.

DOI:10.3109/09273948.2013.791700

PMID:23730797

Abstract

PURPOSE

To investigate whether lacrimal gland uptake on (67)Ga-gallium citrate scintigraphy correlates with histopathologic evidence of sarcoidosis.

METHODS

A retrospective, pilot study of 31 patients with suspected sarcoidosis who underwent gallium scintigraphy and lacrimal gland biopsy. Lacrimal gland gallium uptake was assessed by subjective visual scoring (SVS) and lacrimal uptake ratio (LUR).

RESULTS

Eleven (36%) patients had lacrimal gland biopsies containing noncaseating granulomas. A statistically significant correlation was found between lacrimal gland gallium uptake and biopsy positivity using SVS (p = 0.03) or LUR (p = 0.01). Using SVS, biopsy positivity rate increased from 0 to 50% in patients with mild to intense uptake. Using LUR, biopsy positivity rate increased linearly as the ratio increased from 13% (LUR < 4) to 100% (LUR > 8).

CONCLUSIONS

Lacrimal biopsy positivity rate significantly correlated with gallium uptake on scintigraphy. Both SVS and LUR methods appear to correlate with histologic results and may potentially aid in patient selection for biopsy.

摘要

目的

研究（67）Ga-枸橼酸镓闪烁扫描中泪腺摄取与结节病组织病理学证据是否相关。

方法

对 31 例疑似结节病患者进行回顾性、试点研究，这些患者均接受了镓闪烁扫描和泪腺活检。通过主观视觉评分（SVS）和泪腺摄取比值（LUR）评估泪腺镓摄取情况。

结果

11 例（36%）患者的泪腺活检中含有非干酪样肉芽肿。使用 SVS（p=0.03）或 LUR（p=0.01），泪腺摄取与活检阳性之间存在统计学显著相关性。使用 SVS，摄取轻度至强烈的患者活检阳性率从 0 增加到 50%。使用 LUR，随着比值从 13%（LUR<4）增加到 100%（LUR>8），活检阳性率呈线性增加。