Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, China.
J Gastroenterol Hepatol. 2013 Sep;28(9):1502-6. doi: 10.1111/jgh.12288.
To evaluate the effectiveness and outcomes of endoscopic closure of a gastric fundus perforation using over-the-scope clips (OTSCs) system in a surviving canine model.
Gastric fundus perforations (20-mm diameter) were created by an endoscopic needle-knife in six dogs. The perforations then were closed by the OTSC system. Gastroscopy was performed to evaluate the postoperative perforation healing every week. The animals were sacrificed 4 weeks later to examine the possible intraperitoneal complications, and the healing of the perforation was examined histopathologically.
The gastric fundus perforations could primarily be closed using one OTSC in each experimental dog, and the mean time of the procedure was 17.3 ± 7.6 min (9-26 min). All animals survived without postoperative complications. The OTSC retention was observed in one dog at the end of 4 weeks, and the apparent foreign-body reaction was examined pathologically.
Our surviving animal study demonstrated that the OTSC clip system could reliably close gastric fundus perforations without complications.
评估使用内镜下带线夹系统（OTSC）对存活犬模型的胃底穿孔进行内镜下闭合的效果和结果。
通过内镜下针刀在 6 只犬中造成胃底穿孔（直径 20mm）。然后使用 OTSC 系统闭合穿孔。每周进行胃镜检查评估术后穿孔愈合情况。4 周后处死动物，检查可能的腹腔内并发症，并通过组织病理学检查检查穿孔的愈合情况。
每只实验犬使用一个 OTSC 即可初步闭合胃底穿孔，手术平均时间为 17.3±7.6 分钟（9-26 分钟）。所有动物均无术后并发症存活。在第 4 周末，一只狗出现 OTSC 保留，病理检查可见明显的异物反应。
我们的存活动物研究表明，OTSC 夹系统可以可靠地闭合胃底穿孔而无并发症。
