Graduate School of Medicine, Mie University, Mie, Japan.
Eur J Cancer Care (Engl). 2013 Sep;22(5):617-25. doi: 10.1111/ecc.12067. Epub 2013 Jun 3.
Although a number of genetic studies have attempted to link the multidrug resistance (MDR1) C3435T polymorphism to risk of leukaemia, the results were often inconsistent. The present study aimed at investigating the pooled association using a meta-analysis on the published studies. 1933 cases and 2215 controls of 11 published studies in English before June 2012 were involved in the updated meta-analysis. Furthermore, subgroup analysis was performed in different ethnic and leukaemia subtype groups. This meta-analysis suggests that the MDR1 C3435T polymorphism associate with risk of leukaemia. The effect of the variant on the expression levels and the possible functional role of the variant in leukaemia should be addressed in further studies.
虽然有许多遗传研究试图将多药耐药（MDR1）C3435T 多态性与白血病风险联系起来，但结果往往不一致。本研究旨在通过对已发表研究的荟萃分析来探讨综合关联性。该更新荟萃分析纳入了 11 项之前于 2012 年 6 月前发表的英文研究中的 1933 例病例和 2215 例对照。此外，还在不同的种族和白血病亚型组中进行了亚组分析。本荟萃分析表明，MDR1 C3435T 多态性与白血病风险相关。该变异对表达水平的影响以及该变异在白血病中的可能功能作用应在进一步的研究中加以解决。
