Ganga Harsha V, Noyes Adam, White Charles Michael, Kluger Jeffrey
The Henry Low Heart Center, Hartford Hospital, Hartford, Connecticut.
Pacing Clin Electrophysiol. 2013 Oct;36(10):1308-18. doi: 10.1111/pace.12189. Epub 2013 Jun 3.
Magnesium (Mg) is an important intracellular ion with cardiac metabolism and electrophysiologic properties. A large percentage of patients with arrhythmias have an intracellular Mg deficiency, which is out of line with serum Mg concentrations, and this may explain the rationale for Mg's benefits as an atrial antiarrhythmic agent. A current limitation of antiarrhythmic therapy is that the potential for cardiac risk offsets some of the benefits of therapy. Mg enhances the balance of benefits to harms by enhancing atrial antiarrhythmic efficacy and reducing antiarrhythmic proarrhythmia potential as well as providing direct antiarrhythmic efficacy when used as monotherapy in patients undergoing cardiothoracic surgery.
镁（Mg）是一种对心脏代谢和电生理特性至关重要的细胞内离子。很大一部分心律失常患者存在细胞内镁缺乏，这与血清镁浓度不符，这可能解释了镁作为心房抗心律失常药物有益作用的原理。抗心律失常治疗目前的一个局限性是心脏风险的可能性抵消了部分治疗益处。镁通过增强心房抗心律失常疗效、降低抗心律失常药物致心律失常的可能性，以及在心胸外科手术患者中作为单一疗法使用时提供直接抗心律失常疗效，提高了利弊平衡。
