Department of Family & Community Medicine, University of New Mexico, 1 University of New Mexico, Albuquerque, NM 87131, USA.
Obstet Gynecol Clin North Am. 2013 Jun;40(2):291-316. doi: 10.1016/j.ogc.2013.03.004.
The introduction of testing for high-risk HPV types and P16 immunostaining of CIN2 histologic specimens allows for determination of the risk of progression versus regression for a woman with a particular cytologic or histologic specimen. Observation with serial cytological or colposcopic examinations is now appropriate for women with low-grade histologic lesions as well as pregnant and young women with certain high-grade histologic lesions. Current recommendations for management of high-grade lesions, the efficacy of treatment options (cryotherapy and LEEP), and the immediate (bleeding, infection) and longer term complications (cervical incompetence, preterm delivery) of cervical dysplasia treatment are presented.
高危型 HPV 检测和 CIN2 组织学标本的 P16 免疫染色的引入，使得能够确定特定细胞学或组织学标本的女性进展或消退的风险。对于低级别组织学病变的女性以及某些高级别组织学病变的孕妇和年轻女性，现在适合进行连续细胞学或阴道镜检查观察。目前提出了高级别病变的管理建议、治疗选择（冷冻疗法和 LEEP）的疗效，以及宫颈上皮内瘤变治疗的即刻（出血、感染）和长期（宫颈机能不全、早产）并发症。
