Leleu-Chavain Natascha, Biot Christophe, Chavatte Philippe, Millet Régis
Institut de chimie pharmaceutique Albert Lespagnol, université Lille Nord, EA 4481, IFR114, 3, rue du Pr Laguesse, BP 83, 59006 Lille, France.
Med Sci (Paris). 2013 May;29(5):523-8. doi: 10.1051/medsci/2013295016. Epub 2013 May 28.
Originally used in Asia for the treatment of pain, spasms, nausea and insomnia, marijuana is the most consumed psychotropic drug worldwide. The interest of medical cannabis has been reconsidered recently, leading to many scientific researches and commercialization of these drugs. Natural and synthetic cannabinoids display beneficial antiemetic, anti-inflammatory and analgesic effects in numerous diseases, however accompanied with undesirable effects due to the CB1 receptor. Present researches focus on the design of therapeutical molecules targeting the CB2 receptors, and thus avoiding central side effects and therefore psychotropic effects caused by the CB1 receptor.
大麻最初在亚洲用于治疗疼痛、痉挛、恶心和失眠，是全球消费最多的精神药物。医用大麻的价值最近得到了重新审视，引发了许多相关科学研究以及这些药物的商业化。天然和合成大麻素在众多疾病中显示出有益的止吐、抗炎和镇痛作用，但同时也因CB1受体而伴有不良影响。目前的研究集中在设计靶向CB2受体的治疗性分子，从而避免由CB1受体引起的中枢副作用以及精神方面的影响。
