病理生理学 I：肾脏和交感神经系统。

Pathophysiology I: the kidney and the sympathetic nervous system.

机构信息

Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands.

出版信息

EuroIntervention. 2013 May;9 Suppl R:R42-7. doi: 10.4244/EIJV9SRA8.

Abstract

Recently, catheter-based renal denervation (RDN) has become available. In order to understand better the possible role of RDN as a treatment modality, we first discuss the anatomy and function of the renal nerves in this brief review. Secondly, we address the question - what is the clinical evidence for the involvement of the kidneys and renal nerves in the pathogenesis of sympathetic hyperactivity. Finally, we will discuss how this sympathetic hyperactivity can be reduced, specifically addressing the possible role of RDN.

摘要

最近，基于导管的肾脏去神经术（RDN）已经问世。为了更好地了解 RDN 作为一种治疗方式的可能作用，我们首先在这个简短的综述中讨论肾脏神经的解剖和功能。其次，我们探讨了肾脏和肾脏神经在交感神经过度活跃发病机制中的作用的临床证据。最后，我们将讨论如何减少这种交感神经过度活跃，特别讨论 RDN 的可能作用。