Influence of methylmalonate on the uptake of ketone bodies in vitro by the brain of young rats.
作者信息
Dutra J C, Wajner M, Dutra-Filho C S, Mannmacher C F, Wannmacher C M
机构信息
Department of Biochemistry, UFRGS, Porto Alegre, Brazil.
出版信息
Biochem Soc Trans. 1990 Jun;18(3):421-2. doi: 10.1042/bst0180421.
PMID:2373226
Abstract
摘要
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Influence of methylmalonate on the uptake of ketone bodies in vitro by the brain of young rats.丙二酸单酰对幼鼠大脑体外摄取酮体的影响。
Biochem Soc Trans. 1990 Jun;18(3):421-2. doi: 10.1042/bst0180421.
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Effect of methylmalonate on ketone body metabolism in developing rat brain.丙二酸单酰对发育中大鼠脑内酮体代谢的影响。
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Inhibition by methylmalonate of glycine uptake by synaptosomes from rat spinal cord.丙二酸单甲酯对大鼠脊髓突触体摄取甘氨酸的抑制作用。
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Possible explanation for hyperglycinaemia in propionic acidaemia and methylmalonic acidaemia: propionate and methylmalonate inhibit liver and brain mitochondrial clycine transport.丙酸血症和甲基丙二酸血症中高甘氨酸血症的可能解释：丙酸盐和甲基丙二酸盐抑制肝脏和脑线粒体甘氨酸转运。
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Diminished concentrations of ganglioside N-acetylneuraminic acid (G-NeuAc) in cerebellum of young rats receiving chronic administration of methylmalonic acid.长期给予甲基丙二酸的幼鼠小脑神经节苷脂N-乙酰神经氨酸（G-NeuAc）浓度降低。
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Effect of methylmalonate on in vitro lactate release and carbon dioxide production by brain of suckling rats.丙二酸单甲酯对乳鼠脑体外乳酸释放及二氧化碳生成的影响。
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Failure of the normal ureagenic response to amino acids in organic acid-loaded rats. Proposed mechanism for the hyperammonemia of propionic and methylmalonic acidemia.有机酸负荷大鼠对氨基酸正常尿素生成反应的失败。丙酸血症和甲基丙二酸血症高氨血症的机制探讨。
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Effect of postnatal methylmalonate administration on adult rat behavior.产后给予甲基丙二酸对成年大鼠行为的影响。
Braz J Med Biol Res. 1991;24(6):595-605.
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Neurological dysfunction in methylmalonic acidaemia is probably related to the inhibitory effect of methylmalonate on brain energy production.甲基丙二酸血症中的神经功能障碍可能与甲基丙二酸对脑能量产生的抑制作用有关。
J Inherit Metab Dis. 1997 Nov;20(6):761-8. doi: 10.1023/a:1005359416197.
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