佛波酯诱导的蛋白激酶C下调增强胰岛素受体酪氨酸自身磷酸化：胰岛素受体调节中主要组成性作用的证据 - Suppr

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超能文献

Phorbol ester-induced downregulation of protein kinase C potentiates insulin receptor tyrosine autophosphorylation: evidence for a major constitutive role in insulin receptor regulation.

作者信息

Pillay T S, Whittaker J, Siddle K

机构信息

Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, U.K.

出版信息

Biochem Soc Trans. 1990 Jun;18(3):494-5. doi: 10.1042/bst0180494.

DOI:10.1042/bst0180494

PMID:2373247

Abstract

摘要

相似文献

Phorbol ester-induced downregulation of protein kinase C potentiates insulin receptor tyrosine autophosphorylation: evidence for a major constitutive role in insulin receptor regulation.佛波酯诱导的蛋白激酶C下调增强胰岛素受体酪氨酸自身磷酸化：胰岛素受体调节中主要组成性作用的证据

Biochem Soc Trans. 1990 Jun;18(3):494-5. doi: 10.1042/bst0180494.

Phorbol esters inhibit insulin-induced receptor down-regulation in cultured human lymphocytes: association with diminished insulin receptor autophosphorylation.佛波酯抑制培养的人淋巴细胞中胰岛素诱导的受体下调：与胰岛素受体自身磷酸化减少相关。

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Phorbol ester-mediated protein kinase C interaction with wild-type and COOH-terminal truncated insulin receptors.佛波酯介导的蛋白激酶C与野生型及羧基末端截短型胰岛素受体的相互作用。

J Biol Chem. 1991 Nov 15;266(32):21760-4.

Phorbol esters induce insulin receptor phosphorylation in transfected fibroblasts without affecting tyrosine kinase activity.佛波酯可诱导转染的成纤维细胞中胰岛素受体磷酸化，而不影响酪氨酸激酶活性。

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Activation of protein kinase C stimulates the tyrosine phosphorylation and guanosine triphosphatase-activating protein association of p60 in rat hepatoma cells.蛋白激酶C的激活刺激大鼠肝癌细胞中p60的酪氨酸磷酸化和鸟苷三磷酸酶激活蛋白结合。

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Insulin and phorbol ester stimulate initiation factor eIF-4E phosphorylation by distinct pathways in Chinese hamster ovary cells overexpressing the insulin receptor.胰岛素和佛波酯通过不同途径刺激过表达胰岛素受体的中国仓鼠卵巢细胞中起始因子eIF-4E的磷酸化。

Eur J Biochem. 1996 Feb 15;236(1):40-7. doi: 10.1111/j.1432-1033.1996.00040.x.

Monoclonal antibody to the human insulin receptor, but not insulin, stimulates S6 kinase via human insulin receptors mutated at three major tyrosine autophosphorylation sites.针对人胰岛素受体的单克隆抗体，而非胰岛素，通过在三个主要酪氨酸自磷酸化位点发生突变的人胰岛素受体刺激S6激酶。

J Cell Biochem. 1992 Mar;48(3):324-35. doi: 10.1002/jcb.240480313.

Thyrotropin regulates autophosphorylation and kinase activity in both the insulin and the insulin-like growth factor-I receptors in FRTL5 cells.促甲状腺激素调节FRTL5细胞中胰岛素受体和胰岛素样生长因子-I受体的自身磷酸化及激酶活性。

Endocrinology. 1992 Mar;130(3):1615-25. doi: 10.1210/endo.130.3.1311244.

Protein tyrosine phosphorylation and p56lck modification in IL-2 or phorbol ester-activated human natural killer cells.白细胞介素-2或佛波酯激活的人自然杀伤细胞中的蛋白质酪氨酸磷酸化和p56lck修饰

J Immunol. 1990 Sep 1;145(5):1490-7.

Insulin-stimulated tyrosine phosphorylation of protein kinase C alpha: evidence for direct interaction of the insulin receptor and protein kinase C in cells.胰岛素刺激蛋白激酶Cα的酪氨酸磷酸化：细胞中胰岛素受体与蛋白激酶C直接相互作用的证据。

Biochem Biophys Res Commun. 1994 May 16;200(3):1570-7. doi: 10.1006/bbrc.1994.1630.

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Insulin-mimetic actions of phorbol ester in cultured adult rat hepatocytes. Lack of phorbol-ester-elicited inhibition of the insulin signal.佛波酯在培养的成年大鼠肝细胞中的胰岛素模拟作用。缺乏佛波酯引发的对胰岛素信号的抑制作用。

Biochem J. 1993 Jan 15;289 ( Pt 2)(Pt 2):549-55. doi: 10.1042/bj2890549.

Lipoxygenase metabolites of arachidonic and linoleic acids modulate the adhesion of tumor cells to endothelium via regulation of protein kinase C.花生四烯酸和亚油酸的脂氧合酶代谢产物通过调节蛋白激酶C来调控肿瘤细胞与内皮细胞的黏附。

Cell Regul. 1991 Dec;2(12):1045-55. doi: 10.1091/mbc.2.12.1045.

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