IRCCS Centro Neurolesi "Bonino-Pulejo", S.S.113 via Palermo, Cda Casazza, 98124, Messina, Italy,
Arch Sex Behav. 2014 Jan;43(1):187-9. doi: 10.1007/s10508-013-0137-6. Epub 2013 Jun 4.
Hypersexuality, also referred to as sexually inappropriate behavior and sexual disinhibition, involves persistent, uninhibited sexual behaviors directed at oneself or at others, sometimes associated with neurodegenerative disorders. Choline is a water-soluble essential nutrient, used as a dietary supplement in different diseases. This report was aimed at considering choline intake as a possible cause of iatrogenic hypersexuality. After an evaluation, a 79-year-old man affected by memory loss was diagnosed with mild cognitive impairment and treated with oral choline. After 6 weeks of regular choline assumption, the patient showed a pathological increase in libido with sexual urges. As choline was withdrawn, the hypersexuality disappeared within 5 days. Since hypersexuality may be an underreported and overlooked adverse effect of drugs and dietary supplements acting on the cholinergic pathway, this should be considered when treating and counselling patients with inappropriate sexual behavior.
性欲亢进，也称为性行为不当和性抑制解除，涉及持续的、不受抑制的性行为，针对自己或他人，有时与神经退行性疾病有关。胆碱是一种水溶性必需营养素，在不同疾病中用作膳食补充剂。本报告旨在考虑胆碱摄入作为医源性性欲亢进的可能原因。经过评估，一名 79 岁男性因记忆力丧失被诊断为轻度认知障碍，并接受口服胆碱治疗。在常规服用胆碱 6 周后，患者出现性欲病理性增加和性冲动。当停止服用胆碱后，5 天内性欲亢进消失。由于药物和作用于胆碱能途径的膳食补充剂的不良反应可能被低估和忽视，因此在治疗和咨询有不当性行为的患者时应考虑这一点。
