• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

聚糖介导的免疫反应修饰。

Glycan-mediated modification of the immune response.

作者信息

Madsen Caroline B, Pedersen Anders E, Wandall Hans H

机构信息

Copenhagen Center for Glycomics; Department of Cellular and Molecular Medicine; Faculty of Health and Medical Sciences; University of Copenhagen; Copenhagen, Denmark ; Department of International Health, Immunology and Microbiology; Faculty of Health and Medical Sciences; University of Copenhagen; Copenhagen, Denmark.

出版信息

Oncoimmunology. 2013 Apr 1;2(4):e23659. doi: 10.4161/onci.23659.

DOI:10.4161/onci.23659
PMID:23734320
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3654590/
Abstract

Aberrantly glycosylated tumor antigens represent promising targets for the development of anti-cancer vaccines, yet how glycans influence immune responses is poorly understood. Recent studies have demonstrated that GalNAc-glycosylation enhances antigen uptake by dendritic cells as well as CD4 T-cell and humoral responses, but prevents CD8 T-cell activation. Here, we briefly discuss the relevance of glycans as candidate targets for anti-cancer vaccines.

摘要

异常糖基化的肿瘤抗原是开发抗癌疫苗的有前景的靶点，但聚糖如何影响免疫反应仍知之甚少。最近的研究表明，N-乙酰半乳糖胺糖基化增强了树突状细胞对抗原的摄取以及CD4 T细胞和体液反应，但会阻止CD8 T细胞的激活。在此，我们简要讨论聚糖作为抗癌疫苗候选靶点的相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76bd/3654590/2184033dfbb9/onci-2-e23659-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76bd/3654590/2184033dfbb9/onci-2-e23659-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76bd/3654590/2184033dfbb9/onci-2-e23659-g1.jpg

相似文献

1
Glycan-mediated modification of the immune response.聚糖介导的免疫反应修饰。
Oncoimmunology. 2013 Apr 1;2(4):e23659. doi: 10.4161/onci.23659.
2
Tumour-associated glycan modifications of antigen enhance MGL2 dependent uptake and MHC class I restricted CD8 T cell responses.肿瘤相关糖基化抗原修饰增强了 MGL2 依赖性摄取和 MHC Ⅰ类限制的 CD8 T 细胞反应。
Int J Cancer. 2011 Mar 15;128(6):1371-83. doi: 10.1002/ijc.25458.
3
Glycan-based DC-SIGN targeting vaccines to enhance antigen cross-presentation.基于聚糖的树突状细胞特异性细胞间黏附分子-3 结合非黏附分子靶向疫苗增强抗原交叉呈递。
Mol Immunol. 2013 Sep;55(2):143-5. doi: 10.1016/j.molimm.2012.10.031. Epub 2012 Nov 14.
4
Cross-presentation through langerin and DC-SIGN targeting requires different formulations of glycan-modified antigens.通过 langerin 和 DC-SIGN 靶向的交叉呈递需要不同形式的糖基化修饰抗原。
J Control Release. 2015 Apr 10;203:67-76. doi: 10.1016/j.jconrel.2015.01.040. Epub 2015 Feb 2.
5
Targeting glycan modified OVA to murine DC-SIGN transgenic dendritic cells enhances MHC class I and II presentation.将糖基化修饰的卵清蛋白靶向小鼠树突状细胞特异性细胞间黏附分子-3抓取非整合素（DC-SIGN）转基因树突状细胞可增强MHC I类和II类分子的呈递。
Mol Immunol. 2009 Dec;47(2-3):164-74. doi: 10.1016/j.molimm.2009.09.026. Epub 2009 Oct 8.
6
Glycan elongation beyond the mucin associated Tn antigen protects tumor cells from immune-mediated killing.聚糖延伸超出粘蛋白相关 Tn 抗原可保护肿瘤细胞免受免疫介导的杀伤。
PLoS One. 2013 Sep 6;8(9):e72413. doi: 10.1371/journal.pone.0072413. eCollection 2013.
7
Cancer associated aberrant protein O-glycosylation can modify antigen processing and immune response.癌症相关异常蛋白 O-糖基化可改变抗原加工和免疫反应。
PLoS One. 2012;7(11):e50139. doi: 10.1371/journal.pone.0050139. Epub 2012 Nov 26.
8
Glycans from avian influenza virus are recognized by chicken dendritic cells and are targets for the humoral immune response in chicken.禽类流感病毒的聚糖可被鸡树突状细胞识别，是鸡体体液免疫应答的靶标。
Mol Immunol. 2013 Dec;56(4):452-62. doi: 10.1016/j.molimm.2013.06.007. Epub 2013 Aug 1.
9
Activation of the C-Type Lectin MGL by Terminal GalNAc Ligands Reduces the Glycolytic Activity of Human Dendritic Cells.末端半乳糖胺配体激活 C 型凝集素 MGL 可降低人树突状细胞的糖酵解活性。
Front Immunol. 2020 Feb 25;11:305. doi: 10.3389/fimmu.2020.00305. eCollection 2020.
10
C-type lectins on dendritic cells: key modulators for the induction of immune responses.树突状细胞上的C型凝集素：免疫反应诱导的关键调节因子。
Biochem Soc Trans. 2008 Dec;36(Pt 6):1478-81. doi: 10.1042/BST0361478.

引用本文的文献

1
Mucin-Type O-GalNAc Glycosylation in Health and Disease.黏蛋白型 O-糖基化在健康和疾病中的作用。
Adv Exp Med Biol. 2021;1325:25-60. doi: 10.1007/978-3-030-70115-4_2.
2
Sialyl Tn-expressing bladder cancer cells induce a tolerogenic phenotype in innate and adaptive immune cells.表达唾液酸化Tn的膀胱癌细胞在先天性和适应性免疫细胞中诱导产生耐受性表型。
Mol Oncol. 2014 May;8(3):753-65. doi: 10.1016/j.molonc.2014.02.008. Epub 2014 Mar 6.

本文引用的文献

1
Cancer associated aberrant protein O-glycosylation can modify antigen processing and immune response.癌症相关异常蛋白 O-糖基化可改变抗原加工和免疫反应。
PLoS One. 2012;7(11):e50139. doi: 10.1371/journal.pone.0050139. Epub 2012 Nov 26.
2
Immune recognition of tumor-associated mucin MUC1 is achieved by a fully synthetic aberrantly glycosylated MUC1 tripartite vaccine.肿瘤相关黏蛋白 MUC1 的免疫识别是通过一种完全合成的异常糖基化 MUC1 三聚体疫苗实现的。
Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):261-6. doi: 10.1073/pnas.1115166109. Epub 2011 Dec 14.
3
Seromic profiling of colorectal cancer patients with novel glycopeptide microarray.
新型糖肽微阵列对结直肠癌患者的血清蛋白质组学分析
Int J Cancer. 2011 Apr 15;128(8):1860-71. doi: 10.1002/ijc.25778. Epub 2011 Jan 12.
4
'Dressed for success' C-type lectin receptors for the delivery of glyco-vaccines to dendritic cells.“盛装打扮”的 C 型凝集素受体将糖疫苗递送至树突状细胞。
Curr Opin Immunol. 2011 Feb;23(1):131-7. doi: 10.1016/j.coi.2010.11.011. Epub 2010 Dec 17.
5
Tumour-associated glycan modifications of antigen enhance MGL2 dependent uptake and MHC class I restricted CD8 T cell responses.肿瘤相关糖基化抗原修饰增强了 MGL2 依赖性摄取和 MHC Ⅰ类限制的 CD8 T 细胞反应。
Int J Cancer. 2011 Mar 15;128(6):1371-83. doi: 10.1002/ijc.25458.
6
Signalling through C-type lectin receptors: shaping immune responses.通过C型凝集素受体的信号传导：塑造免疫反应。
Nat Rev Immunol. 2009 Jul;9(7):465-79. doi: 10.1038/nri2569.
7
Carbohydrate-mediated targeting of antigen to dendritic cells leads to enhanced presentation of antigen to T cells.碳水化合物介导的抗原靶向树突状细胞可增强抗原向T细胞的呈递。
Chembiochem. 2008 Jan 25;9(2):294-303. doi: 10.1002/cbic.200700310.
8
Tumor-associated Tn-MUC1 glycoform is internalized through the macrophage galactose-type C-type lectin and delivered to the HLA class I and II compartments in dendritic cells.肿瘤相关的Tn-MUC1糖型通过巨噬细胞半乳糖型C型凝集素内化，并被递送至树突状细胞中的HLA I类和II类区室。
Cancer Res. 2007 Sep 1;67(17):8358-67. doi: 10.1158/0008-5472.CAN-07-1035.
9
O-glycosylated human MUC1 repeats are processed in vitro by immunoproteasomes.O-糖基化的人MUC1重复序列在体外由免疫蛋白酶体进行加工处理。
J Immunol. 2007 Aug 15;179(4):2380-8. doi: 10.4049/jimmunol.179.4.2380.
10
A glycopeptide in complex with MHC class I uses the GalNAc residue as an anchor.一种与MHC I类分子结合的糖肽以N-乙酰半乳糖胺残基作为锚定基团。
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15029-34. doi: 10.1073/pnas.2432220100. Epub 2003 Dec 1.