Matsugi Akiyoshi, Kamata Noriyuki, Tanaka Takahiro, Hiraoka Koichi
Graduate School of Comprehensive Rehabilitation, Osaka Prefecture University, Japan.
Indian J Physiol Pharmacol. 2012 Jul-Sep;56(3):193-200.
The purpose of this study was to investigate whether right index finger movement during visually guided manual tracking task is fluctuated by transcranial magnetic stimulation (TMS) specifically over the cerebellum and is differently fluctuated by TMS over different sites of the cerebellum. TMS was delivered over the left, middle, or right cerebellum, or Pz. Index finger movement and electromyographic response in the first dorsal interosseous were recorded. Fluctuation of the finger movement appeared approximately 100 ms after cerebellar TMS with a probability of approximately 20%. The probability was significantly higher than that after TMS over the Pz or that after sham TMS. The probability was not significantly different among different TMS sites over the cerebellum. The long latency fluctuation of the finger movement during visually guided manual tracking task is evoked by TMS specifically over the cerebellum, but is not preferentially evoked by a specific site of the cerebellum. Cerebellar TMS induced long latency motor response may be useful to investigate the neural pathways activated by TMS over the cerebellum.
本研究的目的是调查在视觉引导的手动跟踪任务中，右手食指运动是否会受到经颅磁刺激（TMS）特别是作用于小脑的刺激的波动影响，以及TMS作用于小脑不同部位时，这种波动是否存在差异。TMS分别施加于左小脑、中小脑、右小脑或Pz点。记录食指运动以及第一背侧骨间肌的肌电图反应。小脑TMS后约100毫秒出现手指运动波动，概率约为20%。该概率显著高于TMS作用于Pz点后或假刺激TMS后的概率。小脑不同TMS部位之间的概率无显著差异。在视觉引导的手动跟踪任务中，手指运动的长潜伏期波动是由TMS专门作用于小脑诱发的，但并非由小脑的特定部位优先诱发。小脑TMS诱发的长潜伏期运动反应可能有助于研究TMS作用于小脑时激活的神经通路。
