[四肽刺激衰老胰腺细胞的功能活性]
[Tetrapeptide stimulates functional activity of the pancreatic cells in aging].
作者信息
Khavinson V Kh, Sevost'ianova N N, Durnova A O, Lin'kova N S, Tarnovskaia S I, Dudkov A V, Kvetnaia T V
出版信息
Adv Gerontol. 2012;25(4):680-4.
In this study the molecular mechanisms of pancreoprotective action of researched tetrapeptide H-Lys-Glu-Asp-Trp-NH2 in aging pancreatic cells of a human were investigated. It is established that the studied tetrapeptide increases the expression of matrix metalloproteinase MMP2, MMP9, serotonin, glycoprotein CD79alpha, antiapoptotic protein Mcl1, proliferation markers PCNA and Ki67 and decreases the expression of proapoptotic protein p53 in aged pancreatic cell cultures. Thus, the capability to activate the expression of signaling molecules--markers of functional activity of pancreatic cells lies behind the clinical effect of studied tetrapeptide observing in elderly patients with type 2 diabetes mellitus.
本研究对所研究的四肽H-Lys-Glu-Asp-Trp-NH2在人类衰老胰腺细胞中的胰腺保护作用分子机制进行了研究。已证实，所研究的四肽可增加衰老胰腺细胞培养物中基质金属蛋白酶MMP2、MMP9、血清素、糖蛋白CD79α、抗凋亡蛋白Mcl1、增殖标志物PCNA和Ki67的表达，并降低促凋亡蛋白p53的表达。因此，在2型糖尿病老年患者中观察到的所研究四肽的临床效果背后，是激活信号分子表达的能力——胰腺细胞功能活性的标志物。
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