Liver Unit, Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, The Netherlands.
Curr Opin Virol. 2013 Aug;3(4):461-7. doi: 10.1016/j.coviro.2013.05.006. Epub 2013 Jun 2.
Chronic infections with the hepatitis C virus (HCV) are a major global health issue. Viral replication is restricted to hepatocytes, and occurs for decades at high replication rates. Over the last decade, it became accepted that HCV-specific CD4(+) and CD8(+) T cells are crucial for protective immunity to HCV. However, a characteristic feature of persistent HCV infection is the dysfunctional T cell response, and over recent years enormous progress has been made in understanding the mechanisms that dampen the antiviral T cell responses in blood and liver of chronic HCV patients and also impact disease progression.
慢性丙型肝炎病毒 (HCV) 感染是一个全球性的重大健康问题。病毒复制仅限于肝细胞，并且以高复制率持续数十年。在过去的十年中，人们普遍认为 HCV 特异性 CD4(+)和 CD8(+)T 细胞对于 HCV 的保护性免疫至关重要。然而，持续性 HCV 感染的一个特征是 T 细胞反应功能失调，近年来在理解抑制慢性 HCV 患者血液和肝脏中抗病毒 T 细胞反应的机制以及影响疾病进展方面取得了巨大进展。
