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Antihistaminic drug olopatadine downmodulates T cell chemotaxis toward CXCL10 by reducing CXCR3 expression, F-actin polymerization and calcium influx in patients with alopecia areata.

作者信息

Ito Taisuke, Fujiyama Toshiharu, Hashizume Hideo, Tokura Yoshiki

机构信息

Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, Japan.

出版信息

J Dermatol Sci. 2013 Oct;72(1):68-71. doi: 10.1016/j.jdermsci.2013.04.029. Epub 2013 May 11.

DOI:10.1016/j.jdermsci.2013.04.029
PMID:23735349
Abstract
摘要

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Increased expression of Cxcr3 and its ligands, Cxcl9 and Cxcl10, during the development of alopecia areata in the mouse.在斑秃小鼠模型的发病过程中,趋化因子受体3(Cxcr3)及其配体Cxcl9和Cxcl10的表达增加。
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