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[胸腺细胞对亚致死剂量照射小鼠脾脏中多能造血肥大细胞数量的影响]

[Effect of thymocytes on the quantity of polypotent hematopoietic mast cells in the spleen of sublethally irradiated mice].

作者信息

Kozlov V A, Kolesnikova S M, Robinson M V, Trufakin V A

出版信息

Tsitologiia. 1975 Mar;17(3):327-31.

PMID:237357
Abstract

With the aid of Till and McCulloch's method, 5 times 10(-6) thymic cells were found to cause an increase in the number of hemopoietic endogenous spleen colonies in syngeneic donor-recipient combination. Thymic cells of C57BL mice had no effect on the number of endogenous colonies in the spleen. 40 times 10(-6) thymic cells administered 24 hr after sublethal irradiation caused an increase in the number of colony forming units in the spleen within 14 days. Possible ways of the thymus effect on hemopoiesis are discussed.

摘要

借助蒂尔和麦卡洛克的方法,发现在同基因供体 - 受体组合中,5×10⁻⁶个胸腺细胞会使造血内源性脾集落数量增加。C57BL小鼠的胸腺细胞对脾内源性集落数量没有影响。在亚致死剂量照射后24小时给予40×10⁻⁶个胸腺细胞,可使14天内脾内集落形成单位数量增加。文中讨论了胸腺影响造血的可能方式。

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