Conjoint Endocrine Laboratory, Clinical Research Centre, Royal Brisbane and Women's Hospital and Pathology Queensland, Herston, Queensland 4029, Australia.
Placenta. 2013 Aug;34(8):716-8. doi: 10.1016/j.placenta.2013.05.005. Epub 2013 Jun 2.
Normal fetal neurological development depends on a regulated supply of maternal thyroid hormone (TH). We have previously demonstrated that transthyretin (TTR) a TH binding protein, is synthesized, secreted and internalized by trophoblast cells and may provide a route for the transfer of TH from mother to fetus. Our objective was to determine if a member of the low-density lipoprotein receptor family mediates TTR or TTR-TH internalization. TTR-TH internalization by JEG-3 cells is reduced in the presence of receptor associated protein (RAP) or albumin suggesting that TTR-TH is internalized through an LDL-receptor dependent endocytic process.
正常的胎儿神经发育依赖于母体甲状腺激素（TH）的稳定供应。我们之前的研究表明，转甲状腺素蛋白（TTR）是一种 TH 结合蛋白，由滋养层细胞合成、分泌和内化，可能为 TH 从母体向胎儿转移提供了一种途径。我们的目的是确定是否存在 LDL 受体家族成员来介导 TTR 或 TTR-TH 的内化。在存在受体相关蛋白（RAP）或白蛋白的情况下，JEG-3 细胞内的 TTR-TH 减少，表明 TTR-TH 是通过 LDL 受体依赖性内吞作用内化的。
