Hydrology and Plonctology Group, Faculty of Sciences of Bizerte, University Carthage, Zarzouna, Tunisia.
Toxicology Unit, Faculty of Veterinary Medicine (UEX), Caceres, Spain.
Environ Toxicol Pharmacol. 2013 Sep;36(2):384-391. doi: 10.1016/j.etap.2013.04.019. Epub 2013 May 15.
The present study is aimed to evaluate the effect of sublethal exposure to the pyrethroid pesticide deltamethrin, according to biometric parameters and important liver biomarkers in the common carp (Cyprinus carpio). Fish were exposed for 4, 15 and 30 days to deltamethrin mixed to the aquaria water at the concentrations of 0.08, 0.4 and 0.8μg/L. The exposure did not affect fish biometric parameters. Glutathione-S-transferase (GST) activity in liver (hepatopancreas) increased in fish exposed to the high concentration of pesticide only after 30 days when compared to controls. A significant increase of malondialdehyde (MDA) content (79.4% and 90.2% of control) was remarked after 15 and 30 days of exposure to the highest concentration of pesticide. Catalase activities (CAT) went up after 4 days of was to the concentration of 0.4μg/L and 0.8μg/L and at 15 days of exposure to 0.4μg/L. The most significant change of glutathione reductase (GR) activity was recorded at the fourth day, when GR activity was significantly increased after exposure to the concentrations of 0.4μg/L and 0.8μg/L of deltamethrin.
本研究旨在评估亚致死暴露于拟除虫菊酯类杀虫剂氯菊酯对鲤鱼（Cyprinus carpio）的生物计量参数和重要肝脏生物标志物的影响。将鱼暴露于浓度为 0.08、0.4 和 0.8μg/L 的氯菊酯混合水中 4、15 和 30 天。暴露没有影响鱼类的生物计量参数。仅在暴露于高浓度农药 30 天后，与对照组相比，肝脏（肝胰腺）中的谷胱甘肽-S-转移酶（GST）活性增加。在暴露于最高浓度农药 15 和 30 天后，丙二醛（MDA）含量显著增加（分别为对照的 79.4%和 90.2%）。CAT 活性在暴露于 0.4μg/L 和 0.8μg/L 的浓度 4 天后上升，在暴露于 0.4μg/L 的 15 天后上升。GR 活性的最大变化发生在第四天，当暴露于 0.4μg/L 和 0.8μg/L 的氯菊酯时，GR 活性显著增加。
