Mazdeh Mehrdokht, Seifirad Soroush, Kazemi Niloofar, Seifrabie Mohammad Ali, Dehghan Arash, Abbasi Hamidreza
Department of Neurology, Hamadan University of Medical Sciences, Hamadan, Iran.
Acta Med Iran. 2013 May 30;51(5):289-92.
Multiple risk factors are introduced for Multiple Sclerosis (MS). Recent studies have suggested a possible correlation between vitamin D deficiency and an increase risk of MS. This study was therefore undertaken to compare vitamin D levels in new cases of MS and their relatives as healthy controls. Seventy five new diagnosed MS patients and 100 matched healthy controls among their relatives were enrolled in this study. Two groups were matched for gender, age, season in which serum level of vitamin D was checked and region and diet. Serum levels of 25-hydroxy vitamin D was measured, recorded and analyzed. Seventy five patients (57 female and 18 male) and 100 healthy subjects (75 female and 25 male) were enrolled in this study. The mean serum levels of 25-hydroxy vitamin D in case and control groups were 11.31 and 17.9 ng/ml, respectively (P=0.003). Compared to the healthy subject, serum levels of vitamin D were significantly lower in patients with MS. This difference was only significant in women. Observed difference of vitamin D levels of both groups were significant in summer. This study continues to support the role of vitamin D deficiency in MS.
多发性硬化症（MS）存在多种风险因素。最近的研究表明维生素D缺乏与MS风险增加之间可能存在关联。因此，本研究旨在比较MS新发病例及其作为健康对照的亲属的维生素D水平。本研究纳入了75例新诊断的MS患者及其100名匹配的亲属作为健康对照。两组在性别、年龄、检查维生素D血清水平的季节、地区和饮食方面进行了匹配。测量、记录并分析了25-羟基维生素D的血清水平。本研究纳入了75例患者（57名女性和18名男性）和100名健康受试者（75名女性和25名男性）。病例组和对照组25-羟基维生素D的平均血清水平分别为11.31和17.9 ng/ml（P = 0.003）。与健康受试者相比，MS患者的维生素D血清水平显著降低。这种差异仅在女性中显著。两组维生素D水平的观察差异在夏季显著。本研究继续支持维生素D缺乏在MS中的作用。
