神经系统自身免疫性疾病动物模型中的神经性疼痛。
Neuropathic pain in animal models of nervous system autoimmune diseases.
机构信息
School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
出版信息
Mediators Inflamm. 2013;2013:298326. doi: 10.1155/2013/298326. Epub 2013 May 8.
Abstract
Neuropathic pain is a frequent chronic presentation in autoimmune diseases of the nervous system, such as multiple sclerosis (MS) and Guillain-Barre syndrome (GBS), causing significant individual disablement and suffering. Animal models of experimental autoimmune encephalomyelitis (EAE) and experimental autoimmune neuritis (EAN) mimic many aspects of MS and GBS, respectively, and are well suited to study the pathophysiology of these autoimmune diseases. However, while much attention has been devoted to curative options, research into neuropathic pain mechanisms and relief has been somewhat lacking. Recent studies have demonstrated a variety of sensory abnormalities in different EAE and EAN models, which enable investigations of behavioural changes, underlying mechanisms, and potential pharmacotherapies for neuropathic pain associated with these diseases. This review examines the symptoms, mechanisms, and clinical therapeutic options in these conditions and highlights the value of EAE and EAN animal models for the study of neuropathic pain in MS and GBS.
摘要
神经病理性疼痛是神经系统自身免疫性疾病（如多发性硬化症 [MS] 和格林-巴利综合征 [GBS]）的常见慢性表现，导致个体严重残疾和痛苦。实验性自身免疫性脑脊髓炎（EAE）和实验性自身免疫性神经炎（EAN）动物模型分别模拟了 MS 和 GBS 的许多方面，非常适合研究这些自身免疫性疾病的病理生理学。然而，尽管人们非常关注治疗选择，但对神经病理性疼痛机制和缓解的研究却有些不足。最近的研究表明，不同 EAE 和 EAN 模型存在多种感觉异常，这使得人们能够研究与这些疾病相关的神经病理性疼痛的行为变化、潜在机制和潜在的药物治疗方法。本文综述了这些疾病的症状、机制和临床治疗选择，并强调了 EAE 和 EAN 动物模型在研究 MS 和 GBS 中神经病理性疼痛的价值。
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