脂质体阿霉素联合射频消融治疗肝细胞癌的完全坏死。
Liposomal doxorubicin plus radiofrequency ablation for complete necrosis of a hepatocellular carcinoma.
机构信息
Center for Interventional Oncology, Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD, U.S.A. ; Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, U.S.A.
出版信息
Curr Oncol. 2013 Jun;20(3):e274-7. doi: 10.3747/co.20.1266.
Abstract
Radiofrequency ablation (rfa) is a standard treatment for small, unresectable hepatocellular carcinomas (hccs). However, rfa for larger tumours is less successful, and intravenous lyso-thermosensitive liposomal doxorubicin during rfa is one technique postulated to potentially address that limitation. This drug-plus-device combination therapy was used to completely treat a hcc in a patient who underwent liver transplantation 79 days later.
摘要
射频消融（RFA）是治疗小的、不可切除的肝细胞癌（HCC）的标准方法。然而，对于较大的肿瘤，RFA 的效果较差，而在 RFA 期间使用静脉注射溶酶体热敏脂质体阿霉素是一种被认为可能解决这一局限性的技术。这种药物加设备联合治疗方法被用于治疗一名患者的 HCC，该患者在 79 天后接受了肝移植。
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J Control Release. 2012 Mar 28;158(3):487-94. doi: 10.1016/j.jconrel.2011.12.011. Epub 2011 Dec 21.
2
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3
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