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β-胡萝卜素对暴露于尼古丁的培养小鼠胚胎的抗致畸作用。

Antiteratogenic Effects of β-Carotene in Cultured Mouse Embryos Exposed to Nicotine.

机构信息

College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Republic of Korea.

出版信息

Evid Based Complement Alternat Med. 2013;2013:575287. doi: 10.1155/2013/575287. Epub 2013 May 8.

DOI:10.1155/2013/575287
PMID:23737837
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3662118/
Abstract

After maternal intake, nicotine crosses the placental barrier and causes severe embryonic disorders and fetal death. In this study, we investigated whether β -carotene has a beneficial effect against nicotine-induced teratogenesis in mouse embryos (embryonic day 8.5) cultured for 48 h in a whole embryo culture system. Embryos exposed to nicotine (1 mM) exhibited severe morphological anomalies and apoptotic cell death, as well as increased levels of TNF- α , IL-1 β , and caspase 3 mRNAs, and lipid peroxidation. The levels of cytoplasmic superoxide dismutase (SOD), mitochondrial manganese-dependent SOD, cytosolic glutathione peroxidase (GPx), phospholipid hydroperoxide GPx, hypoxia inducible factor 1 α , and Bcl-x L  mRNAs decreased, and SOD activity was reduced compared to the control group. However, when β -carotene (1 × 10(-7) or 5 × 10(-7) μM) was present in cultures of embryos exposed to nicotine, these parameters improved significantly. These findings indicate that β -carotene effectively protects against nicotine-induced teratogenesis in mouse embryos through its antioxidative, antiapoptotic, and anti-inflammatory activities.

摘要

母体摄入尼古丁后，会穿过胎盘屏障，导致严重的胚胎畸形和胎儿死亡。在这项研究中，我们研究了β-胡萝卜素是否对在整个胚胎培养系统中培养 48 小时的第 8.5 天的小鼠胚胎（胚胎）中尼古丁引起的畸形是否有有益的作用。暴露于尼古丁（1mM）的胚胎表现出严重的形态异常和细胞凋亡死亡，以及 TNF-α、IL-1β和 caspase 3 mRNA 的水平增加，以及脂质过氧化。细胞质超氧化物歧化酶（SOD）、线粒体锰依赖性 SOD、胞质谷胱甘肽过氧化物酶（GPx）、磷脂氢过氧化物 GPx、缺氧诱导因子 1α和 Bcl-xL mRNA 的水平降低，SOD 活性与对照组相比降低。然而，当β-胡萝卜素（1×10（-7）或 5×10（-7）μM）存在于暴露于尼古丁的胚胎培养物中时，这些参数显著改善。这些发现表明，β-胡萝卜素通过其抗氧化、抗凋亡和抗炎活性，有效防止尼古丁引起的小鼠胚胎畸形。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb5d/3662118/dd987121d64f/ECAM2013-575287.008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb5d/3662118/dd987121d64f/ECAM2013-575287.008.jpg

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