Liu Lin, He Yi-Hua, Li Zhi-An, Zhang Ye, Gu Xiao-Yan, Han Jian-Cheng, Chen Jiao-Yang
Department of Medical Ultrasound, Henan Provincial People's Hospital, Zhengzhou, Henan 450003;
Exp Ther Med. 2013 May;5(5):1501-1505. doi: 10.3892/etm.2013.1012. Epub 2013 Mar 15.
The aim of this study was to determine the diagnostic value of an ROC curve of the antepartum foramen ovale (AFO) size and the ratio of FO size to aorta (AO) size (FO/AO) for the prediction of puerperal atrial septal defect in different gestational weeks (DGWs). A total of 958 cases were divided into five groups according to number of gestational weeks. Comparisons of FO size, AO size and FO/AO were determined by variance analysis. The correlations between FO size, AO size and gestational age were determined using regression analysis and comparisons between atrial septal defect (ASD) diagnosed in DGWs and normal cardiac FO size and FO/AO were analyzed by t-test. ROC curve analysis was used for FO size and FO/AO to predict the demarcation point of puerperal ASD (pASD). The differences between FO size and AO size in the five groups at DGWs were statistically significant (P=0.000). The sizes of FO and AO increased with gestational age. The differences among pASD, normal cardiac FO size and FO/AO were statistically significant (P=0.000). FO size in the five DGW groups (18-22, 23-26, 27-30, 31-34 and 35-40 weeks) was able to predict the demarcation points of pASD, which were 5.02, 5.15, 6.55, 8.55 and 7.90 mm, respectively. The prediction of pASD with AFO size and FO/AO was accurate and may provide reliable reference values in the clinic.
本研究的目的是确定产前卵圆孔（AFO）大小以及卵圆孔大小与主动脉（AO）大小之比（FO/AO）的受试者工作特征（ROC）曲线对不同孕周（DGWs）产后房间隔缺损预测的诊断价值。根据孕周数将958例患者分为五组。通过方差分析确定FO大小、AO大小和FO/AO的比较。使用回归分析确定FO大小、AO大小与胎龄之间的相关性，并通过t检验分析DGWs中诊断的房间隔缺损（ASD）与正常心脏FO大小和FO/AO之间的比较。使用ROC曲线分析FO大小和FO/AO来预测产后ASD（pASD）的分界点。DGWs五组中FO大小和AO大小之间的差异具有统计学意义（P = 0.000）。FO和AO的大小随孕周增加而增加。pASD、正常心脏FO大小和FO/AO之间的差异具有统计学意义（P = 0.000）。五个DGW组（18 - 22、23 - 26、27 - 30、31 - 34和35 - 40周）的FO大小能够预测pASD的分界点，分别为5.02、5.15、6.55、8.55和7.90 mm。用AFO大小和FO/AO预测pASD是准确的，可为临床提供可靠的参考值。
