Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, People's Republic of China.
Org Lett. 2013 Jun 21;15(12):2914-7. doi: 10.1021/ol400841s. Epub 2013 Jun 5.
An efficient catalytic enantioselective hetero-Diels-Alder reaction of Danishefsky's dienes with α-carbonyl esters using a chiral In(III)-pybox complex has been demonstrated. This protocol offers several advantages, including mild reaction conditions, relatively low catalyst loading, and good to excellent enantioselectivities. Furthermore, the absolute configurations of the new alkynyl-containing products were determined by CD spectra in combination with TD-DFT calculations.
已证明使用手性 In(III)-pybox 配合物，Danishefsky 二烯与 α-羰基酯的高效催化对映选择性杂 Diels-Alder 反应是可行的。该方案具有几个优点，包括反应条件温和、催化剂负载量相对较低以及良好到优秀的对映选择性。此外，通过 CD 光谱结合 TD-DFT 计算确定了新的含炔基产物的绝对构型。
