[氨基酸对非洲大蜗牛（Achatina fulica Férussac）已鉴定的自发放电巨型神经元兴奋性的影响]
[The effect of amino acids on the excitability of identified autoactive giant neurons of Achatina fulica Férussac].
作者信息
Takeuchi H, Yokoi I, Mori A, Kohsaka M
出版信息
C R Seances Soc Biol Fil. 1975;169(4):1099-105.
Effects of the following amino acids were examined on the electrical activity of the two giant neurones (PON and TAN) identified in the subesophageal ganglia of Achatina fulica Férussac : L-Asp, L-Thr, L-Ser, L-Glu, L-Pro, Gly, L-alpha-Ala, beta-Ala, L-cysteine, L-cystine, L-Val, L-Met, L-Ileu, L-Leu, L-Tyr, L-Phe, L-Lys, L-His, L-Arg, L-Cit, L-Try, GABA and GABOB. Among these substances, we observed an inhibitory effect of GABA and GABOB on the TAN excitability. GABA showed stronger effect on the TAN than GABOB. This effect of GABA was due to producing hyperpolarization on the TAN membrane. GABA showed a slight excitatory effect on the PON. The effect of GABOB on the PON was very weak and unstable.
研究了以下氨基酸对非洲大蜗牛（Achatina fulica Férussac）食管下神经节中鉴定出的两种巨型神经元（PON和TAN）电活动的影响：L-天冬氨酸、L-苏氨酸、L-丝氨酸、L-谷氨酸、L-脯氨酸、甘氨酸、L-α-丙氨酸、β-丙氨酸、L-半胱氨酸、L-胱氨酸、L-缬氨酸、L-甲硫氨酸、L-异亮氨酸、L-亮氨酸、L-酪氨酸、L-苯丙氨酸、L-赖氨酸、L-组氨酸、L-精氨酸、L-瓜氨酸、L-色氨酸、γ-氨基丁酸（GABA）和γ-氨基-β-羟基丁酸（GABOB）。在这些物质中，我们观察到GABA和GABOB对TAN兴奋性有抑制作用。GABA对TAN的作用比GABOB更强。GABA的这种作用是由于在TAN膜上产生了超极化。GABA对PON有轻微的兴奋作用。GABOB对PON的作用非常微弱且不稳定。
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