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Eur J Clin Pharmacol. 2013 Sep;69(9):1733-5. doi: 10.1007/s00228-013-1538-0. Epub 2013 Jun 6.
2
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Pharmacogenomics J. 2008 Apr;8(2):152-61. doi: 10.1038/sj.tpj.6500454. Epub 2007 Apr 17.
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Single nucleotide polymorphism discovery and functional assessment of variation in the UDP-glucuronosyltransferase 2B7 gene.UDP-葡萄糖醛酸基转移酶2B7基因单核苷酸多态性的发现及变异的功能评估
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Human uridine diphosphate-glucuronosyltransferase UGT2B7 conjugates mineralocorticoid and glucocorticoid metabolites.人尿苷二磷酸葡萄糖醛酸基转移酶UGT2B7可结合盐皮质激素和糖皮质激素代谢产物。
Endocrinology. 2003 Jun;144(6):2659-68. doi: 10.1210/en.2002-0052.
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Octamer transcription factor-1 enhances hepatic nuclear factor-1alpha-mediated activation of the human UDP glucuronosyltransferase 2B7 promoter.八聚体转录因子-1增强肝细胞核因子-1α介导的人尿苷二磷酸葡萄糖醛酸基转移酶2B7启动子的激活。
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Diabetes mellitus reduces activity of human UDP-glucuronosyltransferase 2B7 in liver and kidney leading to decreased formation of mycophenolic acid acyl-glucuronide metabolite.糖尿病会降低人肝和肾中 UDP-葡萄糖醛酸转移酶 2B7 的活性，导致霉酚酸酰基葡萄糖醛酸代谢物生成减少。
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Lithocholic acid decreases expression of UGT2B7 in Caco-2 cells: a potential role for a negative farnesoid X receptor response element.石胆酸降低Caco-2细胞中UGT2B7的表达：法尼醇X受体负反应元件的潜在作用。
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Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs.人肝脏尿苷二磷酸葡萄糖醛酸基转移酶对含羧酸药物进行葡萄糖醛酸化的互补脱氧核糖核酸克隆及表达
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Identifying functional promoter SNPs using allelic imbalance.
Hum Mutat. 2010 Jan;31(1):v. doi: 10.1002/humu.21174.
10
Homo- and hetero-dimerization of human UDP-glucuronosyltransferase 2B7 (UGT2B7) wild type and its allelic variants affect zidovudine glucuronidation activity.人尿苷二磷酸葡萄糖醛酸基转移酶2B7（UGT2B7）野生型及其等位基因变体的同源和异源二聚化影响齐多夫定葡萄糖醛酸化活性。
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Identification of rs11615992 as a novel regulatory SNP for human P2RX7 by allele-specific expression.通过等位基因特异性表达鉴定 rs11615992 为人类 P2RX7 的新型调控 SNP。
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本文引用的文献

1
SNP discovery, expression and cis-regulatory variation in the UGT2B genes.UGT2B 基因中的 SNP 发现、表达和顺式调控变异。
Pharmacogenomics J. 2012 Aug;12(4):287-96. doi: 10.1038/tpj.2011.2. Epub 2011 Mar 1.
2
Allelic imbalance (AI) identifies novel tissue-specific cis-regulatory variation for human UGT2B15.等位基因失衡（AI）鉴定了人类 UGT2B15 的新型组织特异性顺式调控变异。
Hum Mutat. 2010 Jan;31(1):99-107. doi: 10.1002/humu.21145.
3
Quantitative analysis of UDP-glucuronosyltransferase (UGT) 1A and UGT2B expression levels in human livers.人肝脏中尿苷二磷酸葡萄糖醛酸基转移酶（UGT）1A和UGT2B表达水平的定量分析。
Drug Metab Dispos. 2009 Aug;37(8):1759-68. doi: 10.1124/dmd.109.027227. Epub 2009 May 13.
4
Determination of mRNA expression of human UDP-glucuronosyltransferases and application for localization in various human tissues by real-time reverse transcriptase-polymerase chain reaction.人尿苷二磷酸葡萄糖醛酸基转移酶mRNA表达的测定及其在多种人体组织中的定位——实时逆转录聚合酶链反应应用研究
Drug Metab Dispos. 2009 Jan;37(1):32-40. doi: 10.1124/dmd.108.023598. Epub 2008 Oct 6.
5
Genetic polymorphisms in the 5'-flanking region of human UDP-glucuronosyltransferase 2B7 affect the Nrf2-dependent transcriptional regulation.人类尿苷二磷酸葡萄糖醛酸基转移酶2B7 5'侧翼区域的基因多态性影响Nrf2依赖性转录调控。
Pharmacogenet Genomics. 2008 Aug;18(8):709-20. doi: 10.1097/FPC.0b013e32830500c9.
6
Single nucleotide polymorphism discovery and functional assessment of variation in the UDP-glucuronosyltransferase 2B7 gene.UDP-葡萄糖醛酸基转移酶2B7基因单核苷酸多态性的发现及变异的功能评估
Pharmacogenet Genomics. 2008 Aug;18(8):683-97. doi: 10.1097/FPC.0b013e3283037fe4.
7
Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines.UGT1A和UGT2B mRNA在人正常组织及多种细胞系中的表达。
Drug Metab Dispos. 2008 Aug;36(8):1461-4. doi: 10.1124/dmd.108.021428. Epub 2008 May 14.
8
Pharmacokinetic and pharmacodynamic interaction of lorazepam and valproic acid in relation to UGT2B7 genetic polymorphism in healthy subjects.健康受试者中劳拉西泮与丙戊酸的药代动力学和药效学相互作用与UGT2B7基因多态性的关系
Clin Pharmacol Ther. 2008 Apr;83(4):595-600. doi: 10.1038/sj.clpt.6100324. Epub 2007 Aug 8.
9
Influence of the UGT2B7 promoter region and exon 2 polymorphisms and comedications on Acyl-MPAG production in vitro and in adult renal transplant patients.UGT2B7启动子区域和外显子2多态性以及合并用药对体外及成年肾移植患者体内酰基MPAG生成的影响
Pharmacogenet Genomics. 2007 May;17(5):321-30. doi: 10.1097/FPC.0b013e32801430f8.
10
Influence of UGT1A8 and UGT2B7 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients.UGT1A8和UGT2B7基因多态性对日本肾移植受者霉酚酸药代动力学的影响。
Eur J Clin Pharmacol. 2007 Mar;63(3):279-88. doi: 10.1007/s00228-006-0248-2. Epub 2007 Jan 9.

The use of allelic imbalance to ascertain cis-regulation for human UGT2B7 in vivo.

作者信息

Wang Pin-Yi, Huo Dezheng, Sun Chang, Olopade Olufunmilayo I

出版信息

Eur J Clin Pharmacol. 2013 Sep;69(9):1733-5. doi: 10.1007/s00228-013-1538-0. Epub 2013 Jun 6.

DOI:10.1007/s00228-013-1538-0
PMID:23740002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3748163/
Abstract
摘要