First Department of Internal Medicine, Shinshu University School of Medicine, Nagano, Japan.
Med Oncol. 2013;30(3):623. doi: 10.1007/s12032-013-0623-7. Epub 2013 Jun 6.
The present study was performed to evaluate the clinical characteristics and survival outcomes in patients with small cell lung cancer (SCLC) detected by low-dose computed tomography (CT). We retrospectively reviewed clinical records of patients with SCLC treated at our hospital between 1997 and 2011 and selected patients with SCLC detected by CT screening. We identified 12 patients (male/female 11/1; mean age 67.8 years old. Nine patients had limited disease (LD), and 3 had extensive disease (ED). Five LD patients underwent thoracic surgery, and the pathological staging information included stage IA (n = 1), IB (n = 1), IIA (n = 1), and IIIB (n = 2). Although 2 patients with pathological stages IA and IB had >10-year survival, the median survival times (MST) in LD and ED were 25 months (95 % CI 17.0-32.9) and 16 months (95 % CI; not evaluated), respectively. In addition, MST in 12 patients was not significantly different from that in SCLC patients in general care in our hospital. This analysis suggested that CT screening contributes to the detection of early-stage SCLC in patients that are potentially suitable for surgery, but it remains unclear how to improve clinical outcome in patients with SCLC.
本研究旨在评估低剂量计算机断层扫描（CT）检测到的小细胞肺癌（SCLC）患者的临床特征和生存结果。我们回顾性分析了 1997 年至 2011 年在我院治疗的 SCLC 患者的临床记录，并选择了通过 CT 筛查检测到的 SCLC 患者。我们确定了 12 名患者（男/女 11/1；平均年龄 67.8 岁。9 名患者为局限期（LD），3 名患者为广泛期（ED）。5 名 LD 患者接受了胸部手术，病理分期信息包括 IA 期（n=1）、IB 期（n=1）、IIA 期（n=1）和 IIIB 期（n=2）。尽管 2 名 IA 期和 IB 期的患者有超过 10 年的生存，但 LD 和 ED 的中位生存时间（MST）分别为 25 个月（95%CI 17.0-32.9）和 16 个月（95%CI；未评估）。此外，12 名患者的 MST 与我院一般治疗的 SCLC 患者无显著差异。该分析表明，CT 筛查有助于发现潜在适合手术的早期 SCLC 患者，但如何改善 SCLC 患者的临床结局仍不清楚。
