Population Health Research Institute, McMaster University, 1280 Main Street West, HSC 3V51 Hamilton, ON, Canada L8S 4K1.
Diabetologia. 2013 Sep;56(9):1884-7. doi: 10.1007/s00125-013-2959-0. Epub 2013 Jun 6.
Much has been written regarding the recently discontinued Thiazolidinedione Intervention with Vitamin D Evaluation (TIDE) trial (ClinicalTrials.gov NCT00879970; Diabetologia 55: 36-45) and a variety of opinions have been advanced regarding its purpose, context and design (N Engl J Med 397: 959-964). As such, we deemed it appropriate to clarify TIDE's objectives, research questions and design and the clinical equipoise regarding its research questions.
关于最近停止的噻唑烷二酮干预与维生素 D 评估（TIDE）试验（ClinicalTrials.gov NCT00879970；Diabetologia 55：36-45）已经有很多文献报道，并且对于其目的、背景和设计提出了各种意见（N Engl J Med 397：959-964）。因此，我们认为澄清 TIDE 的目标、研究问题和设计以及关于其研究问题的临床均衡是合适的。
