Research and Development Center of Biorational Pesticide, Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, Northwest A&F University, Yangling, Shaanxi 712100, China.
Trans R Soc Trop Med Hyg. 2013 Aug;107(8):471-9. doi: 10.1093/trstmh/trt045. Epub 2013 Jun 4.
The main ingredient of most repellents on the market is DEET, an effective compound that has the disadvantages of toxic reactions as well as damaging effects on plastic and synthetic fabric. DEET alternatives are urgently needed.
The repellent activities of 11 kinds of essential oils were tested against Aedes albopictus Skuse by a Y-tube olfactometer. Using essential oils with high repellent activity as core material and gelatin and gum arabic as wall materials, we prepared microcapsules of essential oils and optimized the preparation process. The microcapsule formulation was then subjected to repellent bioassay on hand skin.
when the dosage of essential oils was 5 µL, the cinnamon oil repellent rate was 87.5% within 10 min and the Herba Schizonepetae oil (HSO) repellent rate was 98.0% within 3 min. Up to 1.5% (w/v) gelatin and 1.5% (w/v) gum arabic (as wall materials), and HSO (as core material) were used to form microcapsules with a 1:1 ratio of core material to wall material.
The ointment preparations effectively protected hand skin exposed to a high-density A. albopictus Skuse rearing cage for 4-5 h. The HSO microcapsule repellent has broad application and development prospects.
市场上大多数驱虫剂的主要成分是避蚊胺（DEET），这是一种有效的化合物，但具有毒性反应以及对塑料和合成织物的损害作用等缺点。因此，急需寻找避蚊胺的替代品。
利用 Y 型嗅觉仪测试了 11 种精油对白纹伊蚊的驱避活性。以驱避活性高的精油为芯材，明胶和阿拉伯胶为壁材，制备精油微胶囊，并对其制备工艺进行优化。然后在手皮肤上进行微胶囊的驱避生物测定。
当精油用量为 5 µL 时，肉桂油在 10 min 内的驱避率为 87.5%，荆芥油在 3 min 内的驱避率为 98.0%。使用 1.5%（w/v）明胶和 1.5%（w/v）阿拉伯胶（作为壁材），以 1:1 的芯材壁材比例形成微胶囊，芯材为荆芥油。
该软膏制剂能有效保护手部皮肤，使其免受高密度饲养的白纹伊蚊 4-5 h 的侵害。荆芥油微胶囊驱避剂具有广阔的应用和发展前景。
