Unit of Endocrinology and Nutrition Hospital Rio Hortega and Center of Investigation of Endocrinology and Clinical Nutrition, Medicine School and University of Valladolid, Valladolid, Spain.
Eur Rev Med Pharmacol Sci. 2013 May;17(10):1321-5.
Malnutrition is associated with patient outcome, hospital stay and costs. The objective of our study was evaluated the relationship of different anthropometric and biochemical nutritional markers with hospital stance (days) and mortality.
A sample of 3087 hospitalized patients in a Universitary Hospital was enrolled. Nutritional status was assessed from anthropometric variables; body mass index (BMI), weight, weight loss in previous three months, tricipital skin fold thickness, midarm muscle circumference and midarm muscle area. Biochemical evaluation was assessed with albumin, prealbumin, transferrin and lymphocytes. Length of hospital stance and mortality were recorded.
A total of 3087 patients were enrolled, mean age was 67.7±18.3 years, weight 63.3±15,7 kg and BMI 23.7±6.8, with a weight loss (3 months) of 6.3±4.6 kg. Length of stay was 24.7±22.1 days. A total of 2583 patients were discharged. Hospital discharge data showed 87.8% of patients went home, and a 12.2% of patients were discharged to a secondary Hospital. A (n=504) 16.3% of patients died. In the multivariate analysis with a dependent variable [length of stay (days)], only albumin levels remained as an independent predictor in the model (F=2.9; p < 0.05), with an increase of 3.1 days in hospital stay (CI 95%: 0.4-5.8) with each decrease of 1 g/dl of albumin. In multivariate analysis, an independent factor that decrease mortality was high albumin levels (hazard ratio: 0.41; 95% CI: 0.22-0.80), adjusted by age and sex.
Our study shows a significant association among serum albumin levels with length of stay in hospital and mortality.
营养不良与患者的预后、住院时间和费用有关。我们研究的目的是评估不同的人体测量学和生化营养指标与住院时间（天）和死亡率的关系。
我们纳入了一家大学医院的 3087 名住院患者作为样本。通过人体测量学变量评估营养状况，包括体重指数（BMI）、体重、过去三个月体重减轻、三头肌皮褶厚度、上臂中部肌肉周长和上臂中部肌肉面积。生化评估采用白蛋白、前白蛋白、转铁蛋白和淋巴细胞进行评估。记录住院时间和死亡率。
共纳入 3087 例患者，平均年龄为 67.7±18.3 岁，体重 63.3±15.7kg，BMI 23.7±6.8kg，3 个月体重减轻 6.3±4.6kg。住院时间为 24.7±22.1 天。共有 2583 例患者出院。出院数据显示，87.8%的患者回家，12.2%的患者出院到二级医院。共有 504 例（16.3%）患者死亡。在因变量为[住院时间（天）]的多变量分析中，只有白蛋白水平仍然是模型中的独立预测因素（F=2.9；p<0.05），白蛋白每降低 1g/dl，住院时间增加 3.1 天（95%CI：0.4-5.8）。在多变量分析中，降低死亡率的独立因素是高白蛋白水平（风险比：0.41；95%CI：0.22-0.80），通过年龄和性别进行调整。
我们的研究表明，血清白蛋白水平与住院时间和死亡率之间存在显著关联。
