Clin Chem Lab Med. 2013 Oct;51(10):2053-62. doi: 10.1515/cclm-2013-0061.
The aim of the study was to identify the diagnostic significance of presepsin in acute abdominal conditions and also to examine the correlation between presepsin, procalcitonin (PCT) and other parameters.
To detect presepsin we used a new rapid method based on a chemiluminescent enzyme immunoassay. The clinical usefulness of presepsin to differentiate bacterial and non-bacterial infection [including systemic inflammation response syndrome (SIRS)] was studied and compared with PCT, C-reactive protein (CRP) and white blood cells (WBC).
The presepsin values in different conditions were (mean±standard deviation): healthy group (n=70) 258.7±92.53 pg/mL; SIRS (n=30) 430.0±141.33 pg/mL; sepsis (n=30) 1508.3±866.6 pg/mL. The presepsin values were significantly higher in patients with sepsis than the SIRS group (p<0.0001, Mann-Whitney U-test). The area under the receiver operating characteristics (ROC) curve (AUC) for discriminating of the SIRS from the sepsis patients was 0.996 for presepsin and it was greater than the AUC of PCT (0.912), CRP (0.857) or WBC (0.777).
The ROC curve of the SIRS patient without infection and the sepsis patient showed that the presepsin concentration was a significantly sensitive indicator of sepsis and useful marker for the rapid diagnosis of sepsis.
本研究旨在确定降钙素原（PCT）和其他参数之间的相关性，并确定降钙素原（PCT）在急性腹部病症中的诊断意义。
采用基于化学发光酶免疫分析的新快速方法检测降钙素原。研究并比较了降钙素原、C 反应蛋白（CRP）和白细胞（WBC）对鉴别细菌和非细菌性感染（包括全身炎症反应综合征（SIRS））的临床价值。
不同条件下的降钙素原值为（平均值±标准差）：健康组（n=70）258.7±92.53 pg/mL；SIRS 组（n=30）430.0±141.33 pg/mL；脓毒症组（n=30）1508.3±866.6 pg/mL。与 SIRS 组相比，脓毒症患者的降钙素原值明显更高（p<0.0001，Mann-Whitney U 检验）。用于鉴别 SIRS 与脓毒症患者的受试者工作特征（ROC）曲线下面积（AUC）为 0.996，明显大于 PCT（0.912）、CRP（0.857）或 WBC（0.777）的 AUC。
无感染 SIRS 患者和脓毒症患者的 ROC 曲线表明，降钙素原浓度是脓毒症的一个非常敏感的指标，是脓毒症快速诊断的有用标志物。
