Shinoda K, Adachi I, Ueno M, Horikoshi I
Department of Hospital Pharmacy, Toyama Medical and Pharmaceutical University, Japan.
Yakugaku Zasshi. 1990 Mar;110(3):186-90. doi: 10.1248/yakushi1947.110.3_186.
Effects of cepharanthine, one of membrane-stabilizing agents, on membrane permeability and on liposomal size were examined. When cepharanthine was added to the lipid before liposome formation, the size of liposome increased and the permeability did not change. On the other hand, when cepharanthine was added to the liposome suspension after liposome formation, no effect was found on liposomal size but the membrane permeability increased and lag time of initial leak of 5 (& 6)-carboxyfluorescein reduced dose-dependently.
研究了膜稳定剂之一的千金藤素对膜通透性和脂质体大小的影响。在脂质体形成前将千金藤素添加到脂质中时，脂质体大小增加且通透性未改变。另一方面，在脂质体形成后将千金藤素添加到脂质体悬浮液中时，未发现对脂质体大小有影响，但膜通透性增加，且5（&6）-羧基荧光素初始泄漏的滞后时间呈剂量依赖性缩短。
