Kul Ayse Nilgun, Ozdemir Semra, Helvaci Aysen, Bulut Cengiz, Dursun Sefik
Department of Internal Medicine, Okmeydani Training and Research Hospital, Istanbul, Turkey.
Department of Biophysics, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Clin Appl Thromb Hemost. 2014 Nov;20(8):779-82. doi: 10.1177/1076029613492009. Epub 2013 Jun 6.
We compared hemorheological parameters in 42 male patients with acute myocardial infarction (AMI), with (n = 22) or without (n = 20) ST-segment elevation and in 20 controls. Plasma and blood viscosity (cP), plasma protein (g/dL) and fibrinogen (mg/dL) concentrations, red (10(6)/µL) and white (10(3)/µL) blood cell counts, hemoglobin concentration (g/dL), and hematocrit (%) were compared. Plasma viscosity was significantly higher in patients with AMI with (P = .012) and without (P = .046) ST-segment elevation than in controls. Patients with AMI with and without ST-segment elevation had significantly lower albumin (P = .002 and P = .009) and globulin (P = .001 and P = .007) concentrations, red blood cell counts (P = .0001 and P = .004), and hematocrit (P = .014 and P = .040) and significantly higher fibrinogen concentrations (P = .0001 and P = .001) than controls. These findings suggest that AMI in males is associated with increased plasma viscosity and fibrinogen concentrations and with decreased albumin and globulin concentrations, erythrocyte count, and hematocrit, regardless of ST-segment elevation.
我们比较了42例男性急性心肌梗死（AMI）患者的血液流变学参数，其中有ST段抬高的患者22例，无ST段抬高的患者20例，并与20名对照组进行了比较。比较了血浆和血液粘度（厘泊）、血浆蛋白（克/分升）和纤维蛋白原（毫克/分升）浓度、红细胞（10⁶/微升）和白细胞（10³/微升）计数、血红蛋白浓度（克/分升）和血细胞比容（%）。有ST段抬高（P = 0.012）和无ST段抬高（P = 0.046）的AMI患者的血浆粘度显著高于对照组。有和无ST段抬高的AMI患者的白蛋白（P = 0.002和P = 0.009）和球蛋白（P = 0.001和P = 0.007）浓度、红细胞计数（P = 0.0001和P = 0.004）和血细胞比容（P = 0.014和P = 0.040）显著低于对照组，而纤维蛋白原浓度（P = 0.0001和P = 0.001）显著高于对照组。这些发现表明，男性AMI与血浆粘度和纤维蛋白原浓度升高以及白蛋白和球蛋白浓度、红细胞计数和血细胞比容降低有关，无论是否有ST段抬高。
