氧化亚氮吸入对丙泊酚所致低血压反应的影响：一项随机对照试验。
The effect of nitrous oxide inhalation on the hypotensive response to propofol: a randomized controlled trial.
作者信息
Yokoe Chizuko, Hanamoto Hiroshi, Boku Aiji, Sugimura Mitsutaka, Morimoto Yoshinari, Kudo Chiho, Niwa Hitoshi
机构信息
Clinical Fellow, Department of Dental Anesthesiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.
Assistant Professor, Department of Dental Anesthesiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Aug;118(2):166-73. doi: 10.1016/j.oooo.2013.03.020. Epub 2013 Jun 4.
OBJECTIVE
Decrease in arterial blood pressure is a prominent adverse reaction during propofol (Disoprivan; AstraZeneca K.K., Osaka, Japan) sedation. The purpose of this prospective randomized study was to explore the effects of nitrous oxide (N2O) on the hypotensive response during propofol sedation.
STUDY DESIGN
Twenty-six healthy volunteers received intravenous sedation with propofol alone (group P, n=13) or a combined technique using 20% N2O and propofol (group N+P, n=13). Propofol was administered by a target-controlled infusion system to attain and maintain a plasma propofol concentration of 1.5μg/mL. Hemodynamic and autonomic parameters were measured.
RESULTS
Mean arterial pressure decreased in both groups, the hypotensive response in group N+P being significantly smaller than in group P. Reduction in the low-frequency power of systolic blood pressure variability, indicative of sympathetic nervous activity, was also smaller in group N+P than in group P.
CONCLUSIONS
Addition of N2O to propofol sedation can attenuate the hypotensive effect of propofol.
目的
动脉血压下降是丙泊酚（得普利麻；阿斯利康日本株式会社，大阪，日本）镇静期间的一种显著不良反应。这项前瞻性随机研究的目的是探讨氧化亚氮（N₂O）对丙泊酚镇静期间低血压反应的影响。
研究设计
26名健康志愿者接受单独丙泊酚静脉镇静（P组，n = 13）或使用20% N₂O与丙泊酚联合技术（N + P组，n = 13）。通过靶控输注系统给予丙泊酚以达到并维持血浆丙泊酚浓度为1.5μg/mL。测量血流动力学和自主神经参数。
结果
两组平均动脉压均下降，N + P组的低血压反应明显小于P组。N + P组中提示交感神经活动的收缩压变异性低频功率降低也小于P组。
结论
丙泊酚镇静中添加N₂O可减弱丙泊酚的降压作用。
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