Department of Diagnostic Imaging, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust, Oswestry, Shropshire SY10 7AG, UK.
Physiol Meas. 2013 Jul;34(7):757-68. doi: 10.1088/0967-3334/34/7/757. Epub 2013 Jun 7.
Bone mineral density at spine and hip is widely used to diagnose osteoporosis. Certain conditions cause changes in bone density at other sites, particularly in the lower limb, with fractures occurring in non-classical locations. Bone density changes at these sites would be of interest for diagnosis and treatment. We describe an application, based on an existing software option for Hologic scanners, which allows reproducible measurement of bone density at six lower limb sites (upper femur, mid-femur, lower femur; upper leg, mid-leg, lower leg). In 30 unselected subjects, referred for bone density, precision (CV%) measured on 2 occasions, separated by repositioning, ranged from 1.7% (mid-femur) to 4.5% at the lowest leg site. Intra-operator precision, measured by three operators on ten subjects on three occasions, was between 1.0% and 2.9%, whilst inter-operator precision was between 1.0% and 3.6%, according to region. These values compare well with those at the spine and upper femur, and in the literature. There was no evidence that this operator agreement improved between occasions 1 and 3. This technique promises to be useful for assessing bone changes at vulnerable sites in the lower limb, in diverse pathological states and in assessing response to treatment.
骨密度在脊柱和臀部被广泛用于诊断骨质疏松症。某些情况下会导致其他部位的骨密度发生变化，特别是在下肢，骨折发生在非典型部位。这些部位的骨密度变化对于诊断和治疗具有重要意义。我们描述了一种应用，基于现有的 Hologic 扫描仪软件选项，该应用允许在六个下肢部位（股骨上段、中段、下段；大腿、小腿、下段）进行可重复的骨密度测量。在 30 名未经选择的因骨密度问题就诊的受试者中，重新定位后的两次测量的精度（CV%）范围为 1.7%（股骨中段）至最低小腿部位的 4.5%。三名操作员在十名受试者的三个部位上进行的内操作员精度测量值在 1.0%至 2.9%之间，而外操作员精度测量值在 1.0%至 3.6%之间，具体取决于区域。这些值与脊柱和股骨上段以及文献中的值相当。没有证据表明这种操作员之间的一致性在第 1 次和第 3 次测量之间有所提高。这项技术有望用于评估下肢脆弱部位、各种病理状态下的骨变化以及评估治疗反应。
