Benylles Amina, Cairns Donald, Cox Philip J, Kay Graeme
School of Pharmacy and Life Sciences, Robert Gordon University, Schoolhill, Aberdeen AB10 1FR, Scotland.
Acta Crystallogr C. 2013 Jun;69(Pt 6):658-64. doi: 10.1107/S0108270113012377. Epub 2013 May 17.
Reaction between cysteamine (systematic name: 2-aminoethanethiol, C2H7NS) and L-(+)-tartaric acid [systematic name: (2R,3R)-2,3-dihydroxybutanedioic acid, C4H6O6] results in a mixture of cysteamine tartrate(1-) monohydrate, C2H8NS(+)·C4H5O6(-)·H2O, (I), and cystamine bis[tartrate(1-)] dihydrate, C4H14N2S2(2+)·2C4H5O6(-)·2H2O, (III). Cystamine [systematic name: 2,2'-dithiobis(ethylamine), C4H12N2S2], reacts with L-(+)-tartaric acid to produce a mixture of cystamine tartrate(2-), C4H14N2S2(2+)·C4H4O6(2-), (II), and (III). In each crystal structure, the anions are linked by O-H···O hydrogen bonds that run parallel to the a axis. In addition, hydrogen bonding involving protonated amino groups in all three salts, and water molecules in (I) and (III), leads to extensive three-dimensional hydrogen-bonding networks. All three salts crystallize in the orthorhombic space group P2(1)2(1)2(1).
半胱胺（系统命名：2-氨基乙硫醇，C₂H₇NS）与L-(+)-酒石酸[系统命名：(2R,3R)-2,3-二羟基丁二酸，C₄H₆O₆]反应生成半胱胺酒石酸盐(1-)一水合物，C₂H₈NS(+)·C₄H₅O₆(-)·H₂O，（I），和胱胺双[酒石酸盐(1-)]二水合物，C₄H₁₄N₂S₂(2+)·2C₄H₅O₆(-)·2H₂O，（III）。胱胺[系统命名：2,2'-二硫代双(乙胺)，C₄H₁₂N₂S₂]与L-(+)-酒石酸反应生成胱胺酒石酸盐(2-)，C₄H₁₄N₂S₂(2+)·C₄H₄O₆(2-)，（II），和（III）的混合物。在每个晶体结构中，阴离子通过与a轴平行的O-H···O氢键相连。此外，所有三种盐中涉及质子化氨基的氢键，以及（I）和（III）中的水分子，形成了广泛的三维氢键网络。所有三种盐都结晶于正交空间群P2(1)2(1)2(1)中。
