Chirality. 2013 Oct;25(10):643-7. doi: 10.1002/chir.22190.
The direct aldol reaction between aryl methyl ketones with aromatic aldehydes in the presence of tetrachlorosilane and a catalytic amount of a chiral bithiophene diphosphine oxide was studied; the product of double aldol addition was isolated as diacetate in good diastereoselectivity (up to 95:5) and enantioselectivities up to 91%. The reaction with heteroaromatic aldehydes was also investigated leading to the corresponding 1,3 diols, in some cases with excellent stereoselectivities.
研究了在四氯化硅和催化量的手性联噻吩双膦氧化物存在下，芳基甲基酮与芳香醛之间的直接羟醛反应；双羟醛加成产物作为二乙酸酯以良好的非对映选择性（高达 95:5）和对映选择性（高达 91%）分离。还研究了与杂芳醛的反应，得到了相应的 1,3-二醇，在某些情况下具有优异的立体选择性。
