阐明有机催化——光辅助不对称离子对催化在手性吡喃翁离子氢化反应中的应用。
Shedding light on organocatalysis-light-assisted asymmetric ion-pair catalysis for the enantioselective hydrogenation of pyrylium ions.
机构信息
Institut für Organische Chemie, RWTH Aachen, Landoltweg 1, 52074 Aachen, Germany.
出版信息
Chemistry. 2013 Jul 22;19(30):9775-9. doi: 10.1002/chem.201300766. Epub 2013 Jun 6.
PMID:23744744
Abstract
A new light-driven asymmetric ion-pair catalysis procedure for the metal-free enantioselective hydrogenation of in situ generated pyrylium ions from readily available chalcones was developed (see scheme). The photo-assisted Brønsted acid catalyzed procedure has broad scope and allows, for the first time, access to valuable 4H-chromenes in good yields and with excellent enantioselectivities.
摘要
开发了一种新的光驱动不对称离子对催化方法，用于无金属对原位生成的吡喃鎓离子的对映选择性氢化，该吡喃鎓离子由易得的查耳酮生成（见方案）。该光辅助的 Brønsted 酸催化方法具有广泛的适用范围，并且首次能够以良好的收率和优异的对映选择性获得有价值的 4H-色烯。
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