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[与多囊卵巢综合征影像表现中的其他体征相比的慢性炎症和代谢综合征]

[Chronic inflammation and metabolic syndrome in comparison with other signs belonging to the image of polycystic ovary syndrome].

作者信息

Marciniak Aleksandra, Nawrocka-Rutkowska Jolanta, Wiśniewska Berenika, Brodowska Agnieszka, Starczewski Andrzej

机构信息

Pomorski Uniwersytet Medyczny w Szczecinie, Klinika Ginekologii i Uroginekologii.

出版信息

Pol Merkur Lekarski. 2013 Apr;34(202):228-31.

Abstract

Polycystic ovary syndrome (PCOS) is a disorder which concern even 5-10% of women in reproductive age. PCOS is a cause of hyperandrogenism and menstrual disorders with chronic anovulation. The most common clinical symptoms observed in PCOS are hirsutism, acne and obesity. Patients with PCOS often suffer from metabolic disorders like insulin resistance, hyperinsulinemia, dyslipidemia, arteriosclerosis and other abnormalities of the metabolic syndrome. 35 to 60% of women with PCOS are obese and about 50% of them have insulin resistance and hyperinsulinemia. The pathogenesis of atherosclerosis emphasizes the role of inflammatory processes. There are a number of markers of the inflammation process. They are also observed in PCOS and may indicate an increased risk of cardiovascular disease in women. More than 46% of women with PCOS can be diagnosed with metabolic syndrome. Because of the fact that patients with PCOS are at higher risk group of the earlier development of complications such as diabetes t 2, atherosclerosis, hypertension and cardiovascular system diseases, it is important to carry out metabolic disorders diagnosis in every patient with PCOS. It will help to estimate the risk of complications and allow for the implementation of prevention or treatment of metabolic diseases belonging to the image of PCOS.

摘要

多囊卵巢综合征(PCOS)是一种影响5%至10%育龄女性的疾病。PCOS是导致高雄激素血症和伴有慢性无排卵的月经紊乱的原因。PCOS最常见的临床症状是多毛、痤疮和肥胖。PCOS患者常患有代谢紊乱,如胰岛素抵抗、高胰岛素血症、血脂异常、动脉硬化和代谢综合征的其他异常情况。35%至60%的PCOS女性肥胖,其中约50%有胰岛素抵抗和高胰岛素血症。动脉粥样硬化的发病机制强调炎症过程的作用。有许多炎症过程的标志物。它们在PCOS中也有发现,可能表明女性患心血管疾病的风险增加。超过46%的PCOS女性可被诊断为代谢综合征。由于PCOS患者处于较早发生2型糖尿病、动脉粥样硬化、高血压和心血管系统疾病等并发症的高风险组,因此对每一位PCOS患者进行代谢紊乱诊断很重要。这将有助于评估并发症风险,并允许实施属于PCOS范畴的代谢疾病的预防或治疗。

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