钯催化 N-对甲苯磺酰腙与吲哚的氧化交叉偶联反应：N-乙烯基吲哚的合成。
Palladium-catalyzed oxidative cross-coupling of N-tosylhydrazones with indoles: synthesis of N-vinylindoles.
机构信息
Engineering Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Xiamen Marine and Gene Drugs, Institutes of Molecular Medicine and School of Biomedical Sciences, Huaqiao University , Xiamen, 361021, China.
出版信息
Org Lett. 2013 Jun 21;15(12):3022-5. doi: 10.1021/ol401217h. Epub 2013 Jun 4.
A general and efficient palladium-catalyzed oxidative cross-coupling reaction of N-tosylhydrazones with indoles providing N-vinylindoles has been developed. The reaction proceeds smoothly with various indoles and N-tosylhydrazones in a stereocontrolled manner, and a wide variety of N-vinylindoles were obtained up to 99% yields for 26 examples.
发展了一种通用且高效的钯催化 N-对甲苯磺酰腙与吲哚的氧化交叉偶联反应，得到 N-乙烯基吲哚。该反应以立体控制的方式顺利进行，各种吲哚和 N-对甲苯磺酰腙可反应，26 个实例中得到高达 99%的 N-乙烯基吲哚产率。
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