Department of Biological Chemistry, University of Athens Medical School, Athens Greece.
Curr Top Med Chem. 2013;13(13):1503-17. doi: 10.2174/15680266113139990099.
MicroRNAs (miRNAs) are an emerging class of highly conserved, non-coding small RNAs that regulate gene expression on the post-transcriptional level by inhibiting the translation of protein from mRNA or by promoting the degradation of mRNA. The involvement of miRNAs in the regulation of lipid metabolism, inflammatory response, cell cycle progression and proliferation, oxidative stress, platelet activation, endothelial function, angiogenesis and plaque formation and rapture indicates important roles in the initiation and progression of atherosclerosis. In the light of this evidence we will review the role of miRNAs in atherosclerosis.
MicroRNAs (miRNAs) 是一类新兴的高度保守的非编码小分子 RNA，通过抑制 mRNA 翻译或促进 mRNA 降解来调节转录后水平的基因表达。miRNAs 参与脂质代谢、炎症反应、细胞周期进展和增殖、氧化应激、血小板激活、内皮功能、血管生成和斑块形成和破裂的调节，表明其在动脉粥样硬化的发生和发展中起着重要作用。有鉴于此，我们将综述 miRNAs 在动脉粥样硬化中的作用。
