1st Cardiology Department, Hippokration Hospital, Athens University Medical School, Athens, Greece.
Curr Top Med Chem. 2013;13(13):1540-7. doi: 10.2174/15680266113139990103.
The increasing prevalence of coronary artery disease (CAD) as well as its' monitoring remain crucial problems and fields of long debate. Thus, several circulating biomarkers have been found during the last decade and examined in terms of their potential to assist in the prognosis of CAD. Of great interest, are small non-coding RNAs (microRNAs or miRNAS or miRs), due to their association with many aspects of CAD. microRNAs circulate in the bloodstream, while they exist in tissues and affect plaque initiation and progression. In addition, they have been found to contribute to the pathophysiology of CAD and to the CAD-related manifestations such as myocardial infarction, heart failure and cardiac arrhythmias. Therefore, evaluating the role of these molecules may be of great importance in the understanding of atherogenesis providing new evidence for diagnosis and prognosis of CAD.
冠状动脉疾病（CAD）的发病率不断上升及其监测仍然是至关重要的问题和长期争论的领域。因此，在过去十年中发现了几种循环生物标志物，并研究了它们在协助 CAD 预后方面的潜力。非常有趣的是，小非编码 RNA（microRNAs 或 miRNAS 或 miRs），因为它们与 CAD 的许多方面有关。microRNAs 存在于血液中，而它们存在于组织中并影响斑块的起始和进展。此外，已经发现它们有助于 CAD 的病理生理学以及与 CAD 相关的表现，如心肌梗死、心力衰竭和心律失常。因此，评估这些分子的作用对于理解动脉粥样硬化的发生可能非常重要，为 CAD 的诊断和预后提供了新的证据。
