Institute for Genome Sciences & Policy, Duke University, 304 Research Drive, Box 90141, Durham, NC 27708, USA.
Pharmacogenomics. 2013 Jun;14(8):957-68. doi: 10.2217/pgs.13.76.
One of the basic questions in the early uses of pharmacogenetic (PGx) testing revolves around the clinical delivery of testing. Because multiple health professionals may play a role in the delivery of PGx testing, various clinical delivery models have begun to be studied. We propose that a partnership between genetic counselors and pharmacists can assist clinicians in the delivery of comprehensive PGx services. Based on their expert knowledge of pharmacokinetics and pharmacodynamics, pharmacists can facilitate the appropriate application of PGx test results to adjust medication use as warranted and act as a liaison to the healthcare team recommending changes in medication based on test results and patient input. Genetic counselors are well-trained in genetics as well as risk communication and counseling methodology, but have limited knowledge of pharmaceuticals. The complementary knowledge and skill set supports the partnership between genetic counselors and pharmacists to provide effective PGx testing services.
在药物遗传学(PGx)检测的早期应用中,一个基本问题是检测的临床实施。由于多个医疗保健专业人员可能在 PGx 检测的实施中发挥作用,因此已经开始研究各种临床实施模式。我们提出,遗传咨询师和药剂师之间的合作可以帮助临床医生提供全面的 PGx 服务。基于他们在药代动力学和药效学方面的专业知识,药剂师可以促进将 PGx 测试结果适当地应用于调整药物使用,根据需要进行调整,并充当与医疗团队的联络人,根据测试结果和患者的意见建议改变药物。遗传咨询师在遗传学以及风险沟通和咨询方法学方面接受了良好的培训,但对药物学的了解有限。互补的知识和技能支持遗传咨询师和药剂师之间的合作,以提供有效的 PGx 检测服务。