Cornel M C, de Jong-van den Berg L T, Koudstaal J, Wiegerinck M A, te Meerman G J, ten Kate L P
Faculteit der Geneeskunde, Vakgroep Medische Genetica, Rijksuniversiteit, Groningen.
Ned Tijdschr Geneeskd. 1990 Jul 14;134(28):1357-61.
Several authors have reported a possible association between IVF or induction of ovulation on the one hand and the occurrence of neural tube defects on the other hand. Here a review is given of recent literature on this subject, including data available from The Netherlands. Collaborative epidemiologic studies are needed to evaluate the potential risks. In individual pregnancies prenatal examination is advised. In spontaneous abortions fetal pathological evaluation is desirable.
几位作者报告了体外受精或诱导排卵一方面与神经管缺陷的发生另一方面之间可能存在的关联。本文对该主题的近期文献进行了综述，包括来自荷兰的可用数据。需要开展合作性流行病学研究来评估潜在风险。对于单胎妊娠，建议进行产前检查。对于自然流产，进行胎儿病理评估是可取的。
