Department of Life Sciences, Ben Gurion University, Beersheva, Israel.
FEMS Microbiol Lett. 2013 Aug;345(2):110-20. doi: 10.1111/1574-6968.12193. Epub 2013 Jun 27.
Sialic acids and the other nonulosonic acid sugars, legionaminic acid and pseudaminic acid, are nine carbon-containing sugars that can be detected as components of the glycans decorating proteins and other molecules in Eukarya and Bacteria. Yet, despite the prevalence of N-glycosylation in Archaea and the variety of sugars recruited for the archaeal version of this post-translational modification, only a single report of a nonulosonic acid sugar in an archaeal N-linked glycan has appeared. Hence, to obtain a clearer picture of nonulosonic acid sugar biosynthesis capability in Archaea, 122 sequenced genomes were scanned for the presence of genes involved in the biogenesis of these sugars. The results reveal that while Archaea and Bacteria share a common route of sialic acid biosynthesis, numerous archaeal nonulosonic acid sugar biosynthesis pathway components were acquired from elsewhere via various routes. Still, the limited number of Archaea encoding components involved in the synthesis of nonulosonic acid sugars implies that such saccharides are not major components of glycans in this domain.
唾液酸和其他非己酮糖，如 legionaminic 酸和 pseudaminic 酸，是九碳糖，可作为真核生物和细菌中糖蛋白和其他分子糖基化的组成部分被检测到。然而，尽管古菌中存在 N-糖基化，并且有多种糖被招募用于这种翻译后修饰的古菌版本，但在古菌 N-连接聚糖中只出现了一种非己酮糖的单一报道。因此，为了更清楚地了解古菌中非己酮糖生物合成的能力，对 122 个测序基因组进行了扫描，以检测这些糖生物合成相关基因的存在。结果表明，虽然古菌和细菌共享唾液酸生物合成的共同途径，但许多古菌非己酮糖生物合成途径的组成部分是通过各种途径从其他地方获得的。尽管如此，参与非己酮糖合成的古菌编码成分的数量有限，这意味着这些糖不是该领域糖蛋白的主要成分。
